EFFECT OF NALTREXONE ADMINISTRATION ON SHORT-TERM MEMORY IN CHRONICALLY ETHANOL-TREATED OUTBRED RATS
| Autor: | Michał Szulc, Ewa Kamińska, Teresa Bobkiewicz-Kozłowska, I. Kaminska, I. Okulicz-Kozaryn, Przemysław Mikołajczak |
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| Rok vydání: | 2004 |
| Předmět: |
Male
Single administration Analysis of Variance Ethanol Dose-Response Relationship Drug Social memory Narcotic Antagonists Short-term memory General Medicine Pharmacology Naltrexone Social recognition Rats chemistry.chemical_compound Memory Short-Term chemistry medicine Animals Alcohol intake Rats Wistar Psychology medicine.drug |
| Zdroj: | Alcohol and Alcoholism. 39:14-19 |
| ISSN: | 1464-3502 |
| DOI: | 10.1093/alcalc/agh010 |
| Popis: | Aims: The purpose of this study was to evaluate the effect of naltrexone treatment for 21 consecutive days on short-term memory in ethanol-preferring and non-preferring outbred rats. Methods: Ethanol preferring, non-preferring and control Wistar rats were treated with naltrexone (0.1 mg/kg intraperitoneally (i.p.)) for 21 consecutive days. Short-term memory was assessed by using an olfactory social recognition test. Results: A single administration of naltrexone (0.1 mg/kg i.p.) to non-ethanol-treated animals facilitated social memory, whereas the drug did not affect short-term memory in either group of chronically ethanol-treated rats. Multiple naltrexone treatment also lowered alcohol intake in ethanol-preferring rats. Conclusion: Naltrexone-ethanol interaction does not seem to produce any negative effect on the short-term memory in outbred rats. |
| Databáze: | OpenAIRE |
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