Toxicological evaluation of an antilithiatic polyherbal Siddha formulation-Sirupeellai Samoola Kudineer in experimental rats
| Autor: | Hannah R. Vasanthi, V. Gayathri, M. Vasanthkumar, G. Ramakrishnan, S. Ananthi, Sarah Kuruvilla, C Chandronitha, V. Muthulakshmi |
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| Rok vydání: | 2010 |
| Předmět: |
Male
No-observed-adverse-effect level Health Toxicology and Mutagenesis India Decoction Pharmacology Kidney Toxicology Rats Sprague-Dawley chemistry.chemical_compound Urolithiasis Toxicity Tests Acute medicine Animals No-Observed-Adverse-Effect Level Creatinine Dose-Response Relationship Drug biology Plant Extracts business.industry Myocardium Acid phosphatase Brain General Medicine Acute toxicity Rats Dose–response relationship Toxicity Tests Subacute medicine.anatomical_structure chemistry Toxicity biology.protein Female Medicine Traditional Plant Preparations business |
| Zdroj: | Human & Experimental Toxicology. 30:952-964 |
| ISSN: | 1477-0903 0960-3271 |
| DOI: | 10.1177/0960327110384522 |
| Popis: | Sirupeellai samoola kudineer (SK), a polyherbal decoction, has been used in Siddha system of medicine for the management of Urolithiasis. Since, there exists no documentation of preclinical toxicological evaluation of SK earlier, in the present study, acute and subacute toxicity of SK was assessed in Sprague Dawley rats as per OECD guideline 423 and 407, respectively. In the acute toxicity study, SK did not produce any toxic signs at a dose level of 50 ml/kg b.wt/p.o. Three doses of SK (4.5, 9.0, 18.0 ml/kg b.wt) were administered and observed for various behavioral, physiological, biochemical, and haematological changes for 28 days in the subacute toxicity study. Low and mid dose of SK (4.5 and 9.0 ml/kg b.wt) did not exhibit any significant physiological and haematological alterations. Whereas, high dose (18.0 ml/kg bw) treatment exhibited significant changes in creatinine, gamma glutamyl transferase (GGT) and acid phosphatase (ACP) levels in serum. Further, histopathological examinations of brain, heart, liver, kidney and sex organs revealed normal architecture signifying no morphological changes upto a dose of 9.0 ml/kg. However, 18.0 ml/kg of SK administration showed few histopathological changes as compared to the control. Based on these results, it can be concluded that Sirupeellai samoola kudineer is safe and non-toxic upto 9.0 ml/kg for 28 days in experimental rats. |
| Databáze: | OpenAIRE |
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