Thyroid-Stimulating Hormone–Stimulated Fused Positron Emission Tomography/Computed Tomography in the Evaluation of Recurrence in 131I-Negative Papillary Thyroid Carcinoma
Autor: | William Pavlosky, George Saab, John Yoo, Thomas J. McDonald, Albert Driedger, Jean-Luc Urbain, Ching-Yee O. Wong |
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Rok vydání: | 2006 |
Předmět: |
Adult
Male endocrine system medicine.medical_specialty endocrine system diseases Endocrinology Diabetes and Metabolism medicine.medical_treatment Thyrotropin Thyroglobulin Iodine Radioisotopes Thyroid carcinoma Endocrinology Thyroid-stimulating hormone Fluorodeoxyglucose F18 medicine Humans Thyroid Neoplasms False Negative Reactions Positron Emission Tomography-Computed Tomography medicine.diagnostic_test business.industry Middle Aged Carcinoma Papillary Elevated thyroglobulin Positron emission tomography Positron-Emission Tomography Female Radiology Neoplasm Recurrence Local business Nuclear medicine Tomography Emission-Computed |
Zdroj: | Thyroid. 16:267-272 |
ISSN: | 1557-9077 1050-7256 |
DOI: | 10.1089/thy.2006.16.267 |
Popis: | Fluorine-18 2-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) detects recurrence of papillary thyroid carcinoma (PTC) in thyroidectomized patients with elevated thyroglobulin (Tg) levels and negative (131)I-whole-body scans. This paper describes the utility of thyroid-stimulating hormone (TSH)-stimulated fused FDG-PET/computed tomography (CT) scanning on our first 15 patients of this population.Patients were prepared for PET/CT imaging with thyroid hormone withdrawal (n = 7) or recombinant human TSH (n = 8). All other imaging before the PET/CT did not demonstrate evidence of recurrence.PET/CT scans revealed active foci in 9 patients, 4 prepared with hypothyroidism, and 5 with exogenous TSH. Positive results were demonstrated even in those with relatively low stimulated-TSH Tg values (13 and 14 microg/L). Six patients with positive PET/CT scans were treated surgically, yielding malignant tissue for 5 of those patients.PET/CT scans performed under TSH stimulation are an effective method of detecting of recurrence of PTC and direct surgical interventions, even in those with persistently elevated but relatively low Tg levels. |
Databáze: | OpenAIRE |
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