Biologically Active Quassinoids and Their Chemistry: Potential Leads for Drug Design
| Autor: | Zhengming Guo, Suryanarayana Vangapandu, Larry A. Walker, Robert W. Sindelar, Robert D. Sindelar |
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| Rok vydání: | 2005 |
| Předmět: |
Drug
Stereochemistry media_common.quotation_subject Quantitative Structure-Activity Relationship Antineoplastic Agents Pharmacognosy Biochemistry Terpene Antimalarials Biological property Drug Discovery Brucea Animals media_common Pharmacology Plants Medicinal Quassins biology Chemistry Organic Chemistry Biological activity biology.organism_classification Triterpenes Terpenoid Drug Design Molecular Medicine Simaroubaceae |
| Zdroj: | Current Medicinal Chemistry. 12:173-190 |
| ISSN: | 0929-8673 |
| Popis: | Quassinoids are highly oxygenated triterpenes, which were isolated as bitter principles from the plants of Simaroubaceae family. Their synthesis has attracted much attention because of the wide spectrum of their biological properties. The most prevalent quassinoids have C-20 picrasane skeleton, some known as bruceolides as they were isolated from the genus Brucea, which showed marked antileukemic and antimalarial activities. |
| Databáze: | OpenAIRE |
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