High Prevalence and Significance of Hepatitis D Virus Infection among Treatment-Naïve HBsAg-Positive Patients in Northern Vietnam
| Autor: | Christian Wollboldt, Le Huu Song, Thirumalaisamy P. Velavan, C.-Thomas Bock, Agnes Bryniok, Bui Tien Sy, Heiner Wedemeyer, Hung Minh Nguyen, Boris A. Ratsch, Peter G. Kremsner, Nguyen Linh Toan, Hoang Van Luong |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male HBsAg Adolescent Genotype Vietnamese viruses lcsh:Medicine medicine.disease_cause Serology Young Adult medicine Prevalence Humans lcsh:Science Aged Hepatitis B virus Multidisciplinary Hepatitis B Surface Antigens business.industry Reverse Transcriptase Polymerase Chain Reaction lcsh:R virus diseases Bilirubin Hepatitis B biochemical phenomena metabolism and nutrition Middle Aged medicine.disease Virology Hepatitis D language.human_language digestive system diseases Vietnam Hepatocellular carcinoma language lcsh:Q Female Hepatitis D virus Hepatitis Delta Virus business Research Article |
| Zdroj: | PLoS ONE PLoS ONE, Vol 8, Iss 10, p e78094 (2013) |
| ISSN: | 1932-6203 |
| Popis: | Background: Hepatitis D virus (HDV) infection is considered to cause more severe hepatitis than hepatitis B virus (HBV) monoinfection. With more than 9.5 million HBV-infected people, Vietnam will face an enormous health burden. The prevalence of HDV in Vietnamese HBsAg-positive patients is speculative. Therefore, we assessed the prevalence of HDV in Vietnamese patients, determined the HDV-genotype distribution and compared the findings with the clinical outcome. Methods: 266 sera of well-characterized HBsAg-positive patients in Northern Vietnam were analysed for the presence of HDV using newly developed HDV-specific RT-PCRs. Sequencing and phylogenetic analysis were performed for HDV-genotyping. Results: The HDV-genome prevalence observed in the Vietnamese HBsAg-positive patients was high with 15.4% while patients with acute hepatitis showed 43.3%. Phylogenetic analysis demonstrated a predominance of HDVgenotype 1 clustering in an Asian clade while HDV-genotype 2 could be also detected. The serum aminotransferase levels (AST, ALT) as well as total and direct bilirubin were significantly elevated in HDV-positive individuals (p |
| Databáze: | OpenAIRE |
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