DDS promotes longevity through a microbiome-mediated starvation signal
| Autor: | Shirley Park, Billie R. Ocampo, Matt Kaeberlein, Sang Chul Park, Shiwen Chen, Young Wan Ha, Ryan Rossner, Yun-ll Lee, Christopher F. Bennett, Jeehae Han, Haeri Choi, Jong-Sun Kang, Sung Chun Cho |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Aging Physiology Metabolite media_common.quotation_subject lcsh:Medicine Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Microbiome Caenorhabditis elegans media_common Methionine biology lcsh:R Longevity Cell Biology biology.organism_classification Metformin Cell biology 030104 developmental biology Mechanism of action chemistry Neurology (clinical) Geriatrics and Gerontology medicine.symptom 030217 neurology & neurosurgery Pyruvate kinase medicine.drug |
| Zdroj: | Translational Medicine of Aging, Vol 3, Iss, Pp 64-69 (2019) |
| ISSN: | 2468-5011 |
| Popis: | The antibiotic diaminodiphenyl sulfone (DDS) is used in combination with other antibiotics as a first line treatment for leprosy. DDS has been previously reported to extend lifespan in Caenorhabditis elegans through inhibition of pyruvate kinase and decreased mitochondrial function. Here we report an alternative mechanism of action by which DDS promotes longevity in C. elegans by reducing folate production by the microbiome. This results in altered methionine cycle metabolite levels mimicking the effects of metformin and lifespan extension that is dependent on the starvation- and hypoxia-induced flavin containing monoxygenase, FMO-2. |
| Databáze: | OpenAIRE |
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