Influence of a deficiency in biotin on the activity of pyruvate carboxylase and on gluconeogenesis from [14C]pyruvates or bicarbonate in mice
| Autor: | P. Favarger, Maria-Luisa Mayobre, Simonne Rous, Sylviane Pasquier |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Blood Glucose
Male Pyruvate decarboxylation Pyruvate dehydrogenase kinase Chemistry Gluconeogenesis Biotin Biotin deficiency Pyruvate dehydrogenase phosphatase Kidney Pyruvate dehydrogenase complex medicine.disease Biochemistry Pyruvate carboxylase Bicarbonates Mice Adipose Tissue Liver Pyruvate carboxylase activity medicine Animals Pyruvates Pyruvate Carboxylase |
| Zdroj: | International Journal of Biochemistry. 10:311-315 |
| ISSN: | 0020-711X |
| DOI: | 10.1016/0020-711x(79)90095-8 |
| Popis: | 1. 1. The present work was undertaken to investigate the effects of biotin deficiency on the mice liver pyruvate carboxylase activity and gluconeogenesis from [14C]labelled pyruvates or bicarbonate. 2. 2. While pyruvate carboxylase was strongly inhibited by biotin deficiency, the incorporation of [14C]labelled precursors into blood glucose remained unaltered. 3. 3. The results obtained clearly show that pyruvate carboxylase exists in excess in the mice liver to permit normal gluconeogenesis under biotin deficiency. |
| Databáze: | OpenAIRE |
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