Risk of all-cause mortality associated with chronic obstructive pulmonary disease and the role of healthy ageing trajectories: a population-based study of middle-aged and older adults
| Autor: | Beatriz Olaya, Albert Sanchez-Niubo, Ivet Bayes-Marin, Josep Maria Haro, Daniel Fernández |
|---|---|
| Přispěvatelé: | Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa, Universitat Politècnica de Catalunya. GRBIO - Grup de Recerca en Bioestadística i Bioinformàtica |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Epidemiology Pulmons -- Malalties obstructives -- Estadístiques Healthy Aging 03 medical and health sciences Pulmonary Disease Chronic Obstructive 0302 clinical medicine Quality of life Medical statistics parasitic diseases medicine Risk of mortality Humans 030212 general & internal medicine Prospective Studies Prospective cohort study Disease burden Aged COPD Matemàtiques i estadística::Estadística aplicada::Estadística biosanitària [Àrees temàtiques de la UPC] business.industry Public health public health General Medicine Middle Aged medicine.disease Europe 030228 respiratory system Ageing chronic airways disease Lungs -- Diseases Obstructive -- Statistics Quality of Life Medicine business Estadística mèdica Demography |
| Zdroj: | BMJ Open, Vol 11, Iss 7 (2021) UPCommons. Portal del coneixement obert de la UPC Universitat Politècnica de Catalunya (UPC) BMJ Open |
| ISSN: | 2044-6055 |
| Popis: | ObjectivesThe aims were to study the risk of all-cause mortality associated with chronic obstructive pulmonary disease (COPD) and healthy ageing trajectories (HAT) in three birth cohorts and to determine the moderating role of HAT in the association between COPD and all-cause mortality.DesignProspective cohort study.SettingData from waves 1 to 5 of The Survey of Health, Ageing and Retirement in Europe.ParticipantsThe total sample was 28 857 community-dwelling individuals aged 50+ years.Main outcomeAll-cause mortality associated with COPD and HAT adjusting for covariates. We performed Aalen additive hazards models to explore these associations. Interactions between COPD and HAT were also explored. Analyses were conducted separately in three birth cohorts (>1945, 1936–1945 and ≤1935). Latent class growth analysis was used to classify participants into HAT.ResultsThree parallel HAT were found in the three birth cohorts (‘low’, ‘medium’ and ‘high’ healthy ageing). Participants with COPD had an increased mortality risk, but this effect was no longer significant after adjusting for covariates. The ‘low’ HAT was associated with increased mortality risk in the three subsamples, although this effect was lower after adjustment. The interaction between COPD and HAT was significant only in the ≤1935 birth cohort, indicating that those with COPD and a ‘low’ trajectory had a greater risk of mortality.ConclusionsThe healthy ageing scale may be a suitable tool to identify patients at higher risk to mitigate disease burden and improve patients’ quality of life. |
| Databáze: | OpenAIRE |
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