tetra-O-Methylnordihydroguaiaretic acid inhibits melanoma in vivo
| Autor: | Joshua D. Lambert, Robert T. Dorr, Barbara N. Timmermann, Ross O. Meyers |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
DNA Replication
Male Cancer Research Pathology medicine.medical_specialty Programmed cell death Lung Neoplasms Cell cycle checkpoint Melanoma Experimental Apoptosis Breast Neoplasms Mice SCID Adenocarcinoma Biology Kidney Membrane Potentials Mice chemistry.chemical_compound In vivo Tumor Cells Cultured medicine Animals Masoprocol Melanoma DNA synthesis Cell growth Cell Cycle Intracellular Membranes Cell cycle Antineoplastic Agents Phytogenic Xenograft Model Antitumor Assays Mitochondria Mice Inbred C57BL Nordihydroguaiaretic acid Liver Oncology chemistry Colonic Neoplasms Cancer research Female Neoplasm Transplantation |
| Zdroj: | Cancer Letters. 171:47-56 |
| ISSN: | 0304-3835 |
| Popis: | tetra-O-methylnordihydroguaiaretic acid is a derivative of a naturally-occurring lignan, nordihydroguaiaretic acid, that has previously been shown to inhibit various cancer types in vitro and in vivo. Additionally, nordihydroguaiaretic acid has been shown to have nephrotoxic effects in the rat. Here we show that tetra-O-methylnordihydroguaiaretic acid inhibits the growth of a number of tumor cell lines in vitro by inducing apoptosis in a non-schedule-dependent manner. Further, this compound inhibits the synthesis of DNA by melanoma cells and causes cell cycle arrest in G0/G1 and G2/M phases of the cell cycle. tetra-O-Methylnordihydroguaiaretic acid also inhibits the growth of both murine and human melanomas and human colon cancer in vivo without apparent hepatic or renal toxicity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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