Amantadine neurotoxicity in a pediatric patient with renal insufficiency
| Autor: | Daniel S. Sitar, Gerald S. Arbus, Dawn K. Strong, David D. Eisenstat, Scott M. Bryson |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
0301 basic medicine
Graft Rejection Reoperation Adolescent Hallucinations Amantadine Hydrochloride Renal function Kidney Function Tests 030226 pharmacology & pharmacy Dopamine agonist 03 medical and health sciences 0302 clinical medicine Central Nervous System Diseases Tremor medicine Amantadine Humans Pharmacology (medical) General Pharmacology Toxicology and Pharmaceutics Kidney transplantation 030109 nutrition & dietetics business.industry Neurotoxicity medicine.disease Creatine Kidney Transplantation Discontinuation Anesthesia Toxicity Female Kidney Diseases business Immunosuppressive Agents medicine.drug |
| Zdroj: | DICP : the annals of pharmacotherapy. 25(11) |
| ISSN: | 1042-9611 |
| Popis: | Amantadine hydrochloride, a dopamine agonist with antiviral and antiparkinsonism properties, is used for the prevention and treatment of influenza A respiratory infections in high-risk populations. The occurrence of amantadine-induced hallucinations and tremors is described in a young, renal transplant patient with declining renal function. Following discontinuation of amantadine, plasma amantadine concentrations were correlated with central nervous system toxicity. In view of the usage of amantadine in renal transplant recipients and the elderly, clinicians must be alert to the possibility of amantadine-induced neurotoxicity in patients with changing renal function. |
| Databáze: | OpenAIRE |
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