Intrinsic T Cell Defects in Systemic Autoimmunity
| Autor: | Philip Kong, Joe Craft, Leah Diane Eardley, Jared M. Odegard, Farida Bouzahzah, Christina E. Zielinski, Jin-Young Choi |
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| Rok vydání: | 2003 |
| Předmět: |
Autoimmune disease
Systemic lupus erythematosus business.industry T-Lymphocytes General Neuroscience T cell Systemic autoimmunity medicine.disease medicine.disease_cause General Biochemistry Genetics and Molecular Biology Autoimmunity Pathogenesis Mice medicine.anatomical_structure History and Philosophy of Science Antigen immune system diseases Immunology medicine Animals Humans Lupus Erythematosus Systemic skin and connective tissue diseases business Anti-SSA/Ro autoantibodies |
| Zdroj: | Annals of the New York Academy of Sciences. 987:60-67 |
| ISSN: | 1749-6632 0077-8923 |
| DOI: | 10.1111/j.1749-6632.2003.tb06033.x |
| Popis: | Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by loss of T cell tolerance to nuclear antigens. Studies in mice and humans have demonstrated that T cells from individuals with lupus are abnormal. Here, we review the known T cell defects in lupus and their possible biochemical nature, genetic causes, and significance for lupus pathogenesis. |
| Databáze: | OpenAIRE |
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