An OspC-Specific Monoclonal Antibody Passively Protects Mice from Tick-Transmitted Infection by Borrelia burgdorferi B31
| Autor: | Robert D. Gilmore, Mbow Ml, Richard G. Titus |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1999 |
| Předmět: |
medicine.drug_class
Immunology Spirochaetaceae Biology Monoclonal antibody Microbiology Epitope Mice Ticks Antigen Borrelia medicine Animals Borrelia burgdorferi Antigens Bacterial Lyme Disease Mice Inbred BALB C Mice Inbred C3H Immunization Passive Antibodies Monoclonal biology.organism_classification bacterial infections and mycoses Virology Infectious Diseases Immunization Microbial Immunity and Vaccines biology.protein Parasitology Female Antibody Bacterial Outer Membrane Proteins |
| Popis: | A murine monoclonal antibody directed against Borrelia burgdorferi B31 outer surface protein C (OspC) antigen was generated by a method whereby borreliae were inoculated into the mouse via the natural transmission mode of tick feeding. Passive immunization with this antibody resulted in protection of C3H/HeJ and outbred mice from a tick-transmitted challenge infection. Immunofluorescence staining of borrelia cells indicated surface exposure of the OspC epitope reactive with the monoclonal antibody. |
| Databáze: | OpenAIRE |
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