Alpha-particle Monte Carlo simulation for microdosimetric calculations using a commercial spreadsheet
| Autor: | John C. Roeske, Mark Hoggarth |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Cytoplasm
Computer science Monte Carlo method Radiation Hybrid Monte Carlo Animals Humans Specific energy Linear Energy Transfer Radiology Nuclear Medicine and imaging Kinetic Monte Carlo Radiometry Simulation Cell Nucleus Stochastic Processes Range (particle radiation) Models Statistical Radiological and Ultrasound Technology Stochastic process Dose-Response Relationship Radiation Radiotherapy Dosage Alpha particle Alpha Particles Computational physics Data Interpretation Statistical Dynamic Monte Carlo method Programming Languages Monte Carlo Method Software Monte Carlo molecular modeling Interpolation |
| Zdroj: | Physics in Medicine and Biology. 52:1909-1922 |
| ISSN: | 1361-6560 0031-9155 |
| Popis: | Alpha-particle emitters are currently being evaluated in the treatment of cancer. Because of the short range and high linear energy transfer (LET) of most therapeutic alpha-particle emitters, there are significant stochastic variations in the energy deposited within the cellular nucleus. Hence microdosimetric spectra are often necessary to interpret biological endpoints. However, alpha-particle microdosimetric codes are not readily available. In this paper, we describe how a commercial spreadsheet may be used to perform a Monte Carlo simulation of alpha-particle transport. Subsequently, this information is used to determine the distribution of path lengths, energy deposited, and specific energy for a single alpha-particle traversal through the cell nucleus. These data may then be used to determine microdosimetric parameters for multiple alpha-particle emissions. In our analysis, comparison of the first and second moments of the single-event spectra with previously published data show agreement on the order of a few per cent. These small discrepancies are due to differences in interpolation of stopping powers between the various algorithms. Thus, the spreadsheet Monte Carlo method represents a simple and efficient method to calculate single-event spectra for alpha-particle emitters. Copies of the spreadsheet are available from the corresponding author upon request. |
| Databáze: | OpenAIRE |
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