sICAM-1 intrathecal synthesis and release during the acute phase in children suffering from Coxsackie A9 and S. pneumoniae meningoencephalitis
| Autor: | Bárbara Padilla-Docal, Elena Noris-García, Piotr Lewczuk, Alexis Rodríguez-Rey, Consuelo Sanchez-Martinez, Alberto Juan Dorta-Contreras, Raisa Bu Coifiu-Fanego, Marlen González-Hernández |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Immunodiffusion Intercellular Adhesion Molecule-1 Serum albumin Coxsackievirus Infections Enzyme-Linked Immunosorbent Assay Guillain-Barre Syndrome medicine.disease_cause cerebrospinal fluid Pneumococcal Infections Coxsackie A9 Cerebrospinal fluid children Meningoencephalitis Streptococcus pneumoniae medicine Humans Child Serum Albumin CSF albumin Inflammation biology business.industry sICAM-1 medicine.disease Intercellular adhesion molecule Enterovirus B Human Immunoglobulin Isotypes stomatognathic diseases Pneumococcal infections Neurology Blood-Brain Barrier Case-Control Studies Child Preschool Immunology biology.protein Neurology (clinical) business Biomarkers |
| Zdroj: | Arquivos de Neuro-Psiquiatria v.66 n.3a 2008 Arquivos de neuro-psiquiatria Academia Brasileira de Neurologia instacron:ABNEURO Scopus-Elsevier |
| ISSN: | 0004-282X |
| Popis: | The intercellular adhesion molecule is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. Serum and cerebrospinal fluid (CSF) soluble intercellular adhesion molecule 1 (sICAM-1) from normal control children as well as from children with Guillain-Barré syndrome (GBS), with Coxsackie A9 virus meningoencephalitis and with Streptococcus pneumoniae meningoencephalitis were studied. sICAM-1 was quantified using an immunoenzimatic assay and albumin using the immunodiffusion technique in both biological fluids. Increased sICAM-1 values in CSF in patients with GBS correspond to an increase of the albumin CSF/serum quotient. In contrast, in inflammatory diseases like S. pneumoniae and Coxsackie A9 virus meningoencephalitis an increased brain-derived fraction was observed. In particular cases these values are 60-65% and 70-75% respectively. The results indicate an additional synthesis of sICAM-1 in subarachnoidal space during central nervous system (CNS) inflammatory process. An important role of sICAM-1 in the transmigration of different cell types into CSF during CNS inflammation in children with S. pneumoniae and Coxsackie A9 meningoencephalitis may be suggested. |
| Databáze: | OpenAIRE |
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