Comparison in rabbits of chole-scintigraphic properties of several 99mTc-IDA derivatives
| Autor: | Liniecki J, Mikiciuk-Olasik E, Kapuściński J, Durski K |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Male
medicine.medical_specialty Metabolic Clearance Rate Glycine Transit time Scintigraphy Excretion Sex Factors Technetium Tc 99m Diethyl-iminodiacetic Acid Internal medicine Medicine Animals Bile Radiology Nuclear Medicine and imaging Radionuclide Imaging Plasma clearance Lagomorpha Aniline Compounds medicine.diagnostic_test biology business.industry Imino Acids Gallbladder Technetium General Medicine Organotechnetium Compounds biology.organism_classification Endocrinology medicine.anatomical_structure Liver Biliary tract Hepatocyte Female Bile Ducts Rabbits business Nuclear medicine Technetium-99m |
| Zdroj: | Nuklearmedizin. Nuclear medicine. 25(5) |
| ISSN: | 0029-5566 |
| Popis: | Pathways and kinetics of excretion were compared to four 99mTc-IDA derivatives in healthy rabbits of both sexes. Assessment of differences between the compounds was based upon: plasma clearance, characteristics of time-activity curves measured scintigraphically over the liver (time of the peak Tmax; time for decline of activity to half the peak value - T50%), and hepatocytic mean transit time (MTT) as derived after deconvolution of the hepatic time-activity curve. Hepatocyte transit time was short and similar to 99mTc-complexes of Mebrofenin, 2,4-diethyl IDA (HEPIDA) and 3-iodo-2,6- diethylphenylcarbamoylmethyliminodiacetic acid (JODIDA); it was evidently longer for 99mTc-p-butyl-IDA (BIDA). 99mTc-HEPIDA displayed significant urinary elimination; the remaining three compounds were excreted practically completely via the biliary route. It is concluded that optimal parameters were displayed by 99mTc-Mebrofenin and 99mTc-JODIDA. |
| Databáze: | OpenAIRE |
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