Levothyroxine replacement in primary congenital hypothyroidism: the higher the initial dose the higher the rate of overtreatment
| Autor: | Gönül Çatlı, Ece Böber, Hale Tuhan, Ahmet Anık, Korcan Demir, Ayhan Abaci, Gizem Cicek |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Endocrinology Diabetes and Metabolism Initial dose Urology Levothyroxine 030209 endocrinology & metabolism 03 medical and health sciences 0302 clinical medicine Endocrinology Thyroid-stimulating hormone 030225 pediatrics Internal medicine Congenital Hypothyroidism medicine Humans Endocrine system Dose-Response Relationship Drug business.industry Thyroid medicine.disease Congenital hypothyroidism Thyroxine Dose–response relationship medicine.anatomical_structure Pediatrics Perinatology and Child Health Population study Female business medicine.drug |
| Zdroj: | Journal of Pediatric Endocrinology and Metabolism. 29 |
| ISSN: | 2191-0251 0334-018X |
| Popis: | BACKGROUND Congenital hypothyroidism (CH) is the most frequent endocrine disorder during the neonatal period, and a delay in diagnosis and treatment leads to irreversible complications. A high L-thyroxine (LT4) dose is recommended for treatment, while the optimal starting dose is still a matter of debate. The objective of this study was to determine the effects of various starting doses of LT4 on serum thyroid stimulating hormone (TSH) and thyroxine (fT4) at the end of the first month of treatment. METHODS A total of 71 patients (37 males, 52.1%) with CH were included in the study. The patients were designated into three sets of subgroups according to the following categorical variables: (i) initial LT4 doses: 6-9.9 μg/kg/day, 10-11.9 μg/kg/day and 12-17 μg/kg/day; (ii) initial TSH levels: 6-9.99 μIU/mL, 10-75 μIU/mL and >75 μIU/mL; and (iii) etiology: dyshormonogenesis and dysgenesis. A fT4 level >2.3 ng/dL±a TSH level |
| Databáze: | OpenAIRE |
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