Myocardial dysfunction and depressed fatty acid metabolism in patients with cyanotic congenital heart disease
| Autor: | Chisato Kondo, Kiyoko Kusakabe, Makoto Nakazawa, Kazuo Momma |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Heart Defects Congenital Male medicine.medical_specialty Adolescent Heart disease Cyanotic congenital heart disease chemistry.chemical_element Fatty Acids Nonesterified Scintigraphy Iodine Radioisotopes chemistry.chemical_compound Internal medicine medicine Humans Ventricular Function Cineangiography Radiology Nuclear Medicine and imaging Child Tomography Emission-Computed Single-Photon medicine.diagnostic_test Fatty acid metabolism Iodobenzenes business.industry Fatty Acids Heart medicine.disease Myocardial Contraction Thallium Radioisotopes medicine.anatomical_structure chemistry Ventricle Child Preschool Cardiology Thallium Female Cardiology and Cardiovascular Medicine business Perfusion |
| Zdroj: | Journal of Nuclear Cardiology. 3:30-36 |
| ISSN: | 1071-3581 |
| DOI: | 10.1016/s1071-3581(96)90021-5 |
| Popis: | Background. Myocardial contractile dysfunction has been frequently observed in adolescents or adults with cyanotic congenital heart disease. Impaired energy metabolism may be present in such dysfunctional myocardium. Methods and Results. To evaluate the findings of myocardial free fatty acid metabolism, and its relations to ventricular wall motion and myocardial perfusion in cyanotic congenital heart disease, we performed a combined study of iodine 123-labeled 15-(p-iodophenyl)-3-(R,S)-methylpentadecanoic acid (BMIPP) scintigraphy, thallium scintigraphy, and contrast cineangiography in seven patients with single right or left ventricle. The results showed that wall motion was reduced in 17 of 35 ventricular segments (49%), which were mostly identical in location to decreased BMIPP uptake. The severity of BMIPP uptake deficit correlated positively with the degree of impairment of wall motion. On the other hand, thallium uptake was abnormal only in 5 of 35 segments (14%), and the severity of the perfusion defect did not correlate with the degree of wall motion abnormality. Conclusions. Contractile dysfunction in cyanotic heart disease was primarily linked to impaired free fatty acid metabolism rather than to myocardial scar as represented by perfusion defect on thallium imaging. |
| Databáze: | OpenAIRE |
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