Lower Diastolic Blood Pressure was Associated with Higher Incidence of Chronic Kidney Disease in the General Population Only in those Using Antihypertensive Medications

Autor: Ryo Kido, Toshiki Moriyama, Koichi Asahi, Masahide Kondo, Kunihiro Yamagata, Shouichi Fujimoto, Yugo Shibagaki, Ichiei Narita, Masato Kasahara, Ayami Ando, Masaru Murasawa, Kunitoshi Iseki, Tsuneo Konta, Kazuhiko Tsuruya, Hiroo Kawarazaki, Tsuyoshi Watanabe, Daisuke Uchida
Rok vydání: 2019
Předmět:
Adult
Male
lcsh:Diseases of the circulatory (Cardiovascular) system
medicine.medical_specialty
Population
030232 urology & nephrology
Renal function
Blood Pressure
Subgroup analysis
lcsh:RC870-923
03 medical and health sciences
0302 clinical medicine
Diastolic blood pressure
Chronic kidney disease
Internal medicine
Epidemiology
lcsh:Dermatology
Humans
Medicine
Renal Insufficiency
Chronic
education
Antihypertensive Agents
Aged
education.field_of_study
Antihypertensive medication
business.industry
Incidence
Incidence (epidemiology)
General population
General Medicine
Middle Aged
lcsh:RL1-803
lcsh:Diseases of the genitourinary system. Urology
medicine.disease
Blood pressure
lcsh:RC666-701
Nephrology
Hypertension
Female
Cardiology and Cardiovascular Medicine
business
Risk assessment
circulatory and respiratory physiology
Kidney disease
Zdroj: Kidney & Blood Pressure Research, Pp 1-11 (2019)
ISSN: 1423-0143
1420-4096
Popis: Background/Aims: The association of diastolic blood pressure (DBP) with incidence of chronic kidney disease (CKD) in the general population is not well examined. Methods: Using national health check-up database from 2008 to 2011 in the general Japanese population aged 39–74 years, we evaluated the association between DBP and incidence of CKD 2 years later in 127,954 participants without CKD. DBP was categorized by every 5 mm Hg from the lowest (100 mm Hg) and was further stratified into those with and without antihypertensive medications (BP meds). We calculated the OR for estimating adjusted risk of incident CKD using logistic regression model. Results: Participants were 62% female and 25.9% with BP meds, mean age of 76 years with estimated glomerular filtration rate of 78.2 ± 13.4 and DBP of 76 ± 11 mm Hg. Two years later, 12,379 (9.7%) developed CKD. Compared to DBP 60–64 mm Hg without BP meds as reference, multivariate analysis showed no difference in CKD risk at any DBP category among those without BP meds. However, in those with BP meds, risk increased according to lower DBP from 95 to 60 mm Hg (p for trend 0.05) with OR 1.51 (95% CI 1.14–1.99) in DBP p for trend 0.02) only in those without BP meds. Conclusion: Lower DBP was associated with higher risk of incident CKD only in the general population taking antihypertensive medication.
Databáze: OpenAIRE
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