Epidemiology of Childhood Hyperthyroidism in France: A Nationwide Population-Based Study
| Autor: | Alain Le Tertre, Marie Simon, Perrine de Crouy-Chanel, Abdelkrim Zeghnoun, Florentia Kaguelidou, Juliane Léger, Annabel Rigou, Joëlle Le Moal |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Down syndrome Adolescent Cross-sectional study Endocrinology Diabetes and Metabolism Clinical Biochemistry 030209 endocrinology & metabolism Context (language use) Hyperthyroidism Biochemistry 03 medical and health sciences symbols.namesake 0302 clinical medicine Endocrinology Internal medicine Epidemiology medicine Humans Registries 030212 general & internal medicine Poisson regression Age of Onset Child Type 1 diabetes business.industry Incidence Incidence (epidemiology) Biochemistry (medical) Infant medicine.disease Cross-Sectional Studies Child Preschool symbols Female France Age of onset business Demography |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 103:2980-2987 |
| ISSN: | 1945-7197 0021-972X |
| Popis: | Context Hyperthyroidism affects all age groups, but epidemiological data for children are scarce. Objective To perform a nationwide epidemiological survey of hyperthyroidism in children and adolescents. Design A cross-sectional descriptive study. Setting Identification of entries corresponding to reimbursements for antithyroid drugs in the French national insurance database. Participants All cases of childhood hyperthyroidism (6 months to 17 years of age) in 2015. Main Outcome Measures National incidence rate estimated with a nonlinear Poisson model and spatial distribution of cases. Results A total of 670 cases of childhood hyperthyroidism were identified. Twenty patients (3%) had associated autoimmune or genetic disease, with type 1 diabetes and Down syndrome the most frequent. The annual incidence for 2015 was 4.58/100,000 person-years (95% CI 3.00 to 6.99/100,000). Incidence increased with age, in both sexes. This increase accelerated after the age of 8 in girls and 10 in boys and was stronger in girls. About 10% of patients were affected before the age of 5 years (sex ratio 1.43). There was an interaction between age and sex, the effect of being female increasing with age: girls were 3.2 times more likely to be affected than boys in the 10 to 14 years age group and 5.7 times more likely to be affected in the 15 to 17 years age group. No conclusions about spatial pattern emerged. Conclusion These findings shed light on the incidence of hyperthyroidism and the impact of sex on this incidence during childhood and adolescence. The observed incidence was higher than expected from the results published for earlier studies in Northern European countries. |
| Databáze: | OpenAIRE |
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