Visual short-term memory relates to tau and amyloid burdens in preclinical autosomal dominant Alzheimer’s disease
Autor: | Ana Baena, Reisa A. Sperling, Aaron P. Schultz, David S. Jin, Juna Khang, Mario A. Parra, Eric M. Reiman, Keith A. Johnson, Dorene M. Rentz, Francisco Lopera, Edmarie Guzmán-Vélez, Yakeel T. Quiroz, Enmanuelle Pardilla-Delgado, Joshua Fuller, Daniel J. Norton, Nicholas Andrea |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
medicine.medical_specialty Neurology Amyloid Cognitive Neuroscience tau Proteins Disease lcsh:RC346-429 Presenilin lcsh:RC321-571 Temporal lobe 03 medical and health sciences 0302 clinical medicine Neurochemical Alzheimer Disease Presenilin-1 Medicine Humans Cognitive Dysfunction Visual short-term memory Tau PET lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry lcsh:Neurology. Diseases of the nervous system Amyloid beta-Peptides business.industry Research Associative memory Binding Entorhinal cortex Magnetic Resonance Imaging 030104 developmental biology Autosomal dominant Alzheimer’s disease Cross-Sectional Studies Memory Short-Term Positron-Emission Tomography Neurology (clinical) business Neuroscience 030217 neurology & neurosurgery Biomarkers |
Zdroj: | Alzheimer's Research & Therapy Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-11 (2020) |
ISSN: | 1758-9193 |
Popis: | Background Over the past decade, visual short-term memory (VSTM) binding tests have been shown to be one of the most sensitive behavioral indicators of Alzheimer’s disease (AD), especially when they require the binding of multiple features (e.g., color and shape). Recently, it has become possible to directly measure amyloid and tau levels in vivo via positron emission tomography (PET). To this point, these behavioral and neurochemical markers have not been compared in humans with AD or at risk for it. Methods In a cross-sectional study, we compared VSTM performance to tau and amyloid concentrations, measured by PET, in individuals certain to develop AD by virtue of their inheritance of the presenilin-1 E280A mutation. These included 21 clinically unimpaired subjects and 7 subjects with early mild cognitive impairment (MCI), as well as 30 family members who were not carriers of the mutation. Results We found that VSTM performance correlated strongly with tau in entorhinal cortex and inferior temporal lobe, and also with amyloid when examining asymptomatic carriers only. The condition requiring binding was not preferentially linked to tau—in fact, the non-binding “shape only” condition showed a stronger relationship. Conclusions The results confirm VSTM’s status as an early marker of AD pathology and raise interesting questions as to the course of binding-specific versus non-binding aspects of VSTM in early AD. |
Databáze: | OpenAIRE |
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