PDE-5 inhibitors in monotherapy versus combination therapy in a sample of 1200 patients with erectile dysfunction
| Autor: | José Antonio Mirón-Canelo, Luis Labairu-Huerta, Agustín Martín-Rodríguez, Bárbara Padilla-Fernández, José Luis Arrondo-Arrondo, Lauro Sebastián Valverde-Martínez, María Begoña García-Cenador, J.M. Silva-Abuín, María Fernanda Lorenzo-Gómez |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Combination therapy Vasodilator Agents Urology medicine.medical_treatment Physical examination lcsh:RC870-923 Pharmacotherapy Erectile Dysfunction Internal medicine Humans Medicine Testosterone Medical history Alprostadil Retrospective Studies medicine.diagnostic_test business.industry Retrospective cohort study Penile prosthesis Middle Aged Phosphodiesterase 5 Inhibitors lcsh:Diseases of the genitourinary system. Urology medicine.disease Surgery PDE-5 inhibitors Exact test Treatment Outcome Erectile dysfunction Spain Androgens Drug Therapy Combination business Follow-Up Studies |
| Zdroj: | Archivio Italiano di Urologia e Andrologia, Vol 87, Iss 3, Pp 204-209 (2015) |
| ISSN: | 2282-4197 1124-3562 |
| DOI: | 10.4081/aiua.2015.3.204 |
| Popis: | Objectives: To compare the effectiveness in the treatment of erectile dysfunction when using PDE-5 inhibitors (PDE5i), alprostadil (PG-E1) and testosterone (TES) in monotherapy or combination therapy. Material and Methods: Observational multicentre retrospective study of men diagnosed and treated for ED between January 2008 and January 2014. Age, social and employment situation, pathological medical history, risk factors, usual treatments, IIEF-5 at the first consultation and at first and each 6 months follow-ups, physical examination, calculated total and free testosterone and received treatment were analysed. Descriptive statistics, one-way ANOVA analysis, Chi2 for qualitative data, t-test, Fisher's exact test and Pearson's correlation coefficient were used; p < 0.05 is considered significant. Results: Average age was 58.61 years, SD5.02, average follow- up time 48.21 months, SD 6.21, range 6-174 months. Out of the patients 76.12% were married, 9.81% divorced/separated, 10.04% single, 4.03% widowed; 85.14% of the total in stable partnership but 66.16% were not accompanied by their partners. In total 844 patients received monotherapy (597 PDE5i; 62 PG-E1; 36 TES; 27 penile prosthesis; 121 psychotherapy/alternative therapies) and 357 combination therapy (167 PDE5i+TES; 124 PDE5i+PGE1; 66 PG-E1+TES). There was a homogeneous distribution between risk factors and medical history groups. Satisfactory response according to IIEF-5 was achieved for 72.33% of patients on PDE5i monotherapy, 46.65% of patients on PDE5i+PG-E1 combination therapy and 83.41% of patients on PDE5i+TES. Conclusions: The best therapeutic success for ED in this series was achieved through a combination of testosterone+PDE-5 inhibitors without increasing morbidity and maintaining the response over time. Larger studies with longer follow-up will corroborate these findings. |
| Databáze: | OpenAIRE |
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