Impairment of natural killer cell activity in Indian kala-azar: restoration of activity by interleukin 2 but not by alpha or gamma interferon
| Autor: | D. Basu, Partha Pratim Manna, Ganes Chakrabarti, Kamal Kumar Mallik, Sumitra Bhattacharya, Santu Bandyopadhyay, Dwaipayan Bharadwaj |
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| Rok vydání: | 1993 |
| Předmět: |
Adult
Male Interleukin 2 Adolescent medicine.medical_treatment Immunology Alpha interferon Biology Microbiology Natural killer cell Interferon-gamma parasitic diseases medicine Humans Interferon gamma Child Interferon alfa Lymphokine-activated killer cell Recombinant Proteins Killer Cells Natural Infectious Diseases medicine.anatomical_structure Cytokine Interferon Type I Interleukin 12 Interleukin-2 Leishmaniasis Visceral Female Parasitology Research Article medicine.drug |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1098-5522 0019-9567 |
| DOI: | 10.1128/iai.61.8.3565-3569.1993 |
| Popis: | Indian kala-azar patients have normal numbers of peripheral blood NK cells but impaired functional activity due to decreased binding and lysis of target cells. This impairment of NK activity could not be corrected by exogenous recombinant human alpha or gamma interferon. However, recombinant human interleukin 2 was able to restore this activity by augmenting conjugate formation and lysis of target cells. |
| Databáze: | OpenAIRE |
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