Lymphomyeloid Contribution of an Immune-Restricted Progenitor Emerging Prior to Definitive Hematopoietic Stem Cells
| Autor: | Christina Jensen, Marella F. T. R. de Bruijn, Ewa Sitnicka, Adam J. Mead, Elisa Gomez Perdiguero, Shabnam Kharazi, Qiaolin Deng, Deborah Atkinson, Frederic Geissmann, Luca Melchiori, Anne Hultquist, Iain C. Macaulay, Emanuele Azzoni, Joana Carrelha, Sidinh Luc, Annica Pontén, Joanna C. A. Green, Sten Eirik W. Jacobsen, Isabelle Godin, Tiphaine Bouriez-Jones, Tiago C. Luis, Petter S. Woll, Michael Lutteropp, Rickard Sandberg, Gemma Swiers, Charlotta Böiers |
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| Přispěvatelé: | Hématopoïèse normale et pathologique (U1170 Inserm), Université Paris-Sud - Paris 11 (UP11)-Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Böiers, C, Carrelha, J, Lutteropp, M, Luc, S, Green, J, Azzoni, E, Woll, P, Mead, A, Hultquist, A, Swiers, G, Perdiguero, E, Macaulay, I, Melchiori, L, Luis, T, Kharazi, S, Bouriez-Jones, T, Deng, Q, Pontén, A, Atkinson, D, Jensen, C, Sitnicka, E, Geissmann, F, Godin, I, Sandberg, R, de Bruijn, M, Jacobsen, S |
| Rok vydání: | 2013 |
| Předmět: |
Male
Myeloid Biology Polymerase Chain Reaction Mice 03 medical and health sciences 0302 clinical medicine Genetics medicine Animals Myeloid Cells Lymphocytes Lymphopoiesis Myeloid Cell Cells Cultured ComputingMilieux_MISCELLANEOUS 030304 developmental biology Interleukin 3 0303 health sciences Innate immune system Animal Gene Expression Regulation Developmental Hematopoietic Stem Cell Cell Differentiation Cell Biology Hematopoietic Stem Cells Embryonic stem cell Endothelial stem cell Haematopoiesis [SDV.BDD.EO]Life Sciences [q-bio]/Development Biology/Embryology and Organogenesis medicine.anatomical_structure 030220 oncology & carcinogenesis Immunology Molecular Medicine Lymphocyte Female Stem cell |
| Zdroj: | Cell Stem Cell Cell Stem Cell, Cambridge, MA : Cell Press, 2013, 13 (5), pp.535-548. ⟨10.1016/j.stem.2013.08.012⟩ Scopus-Elsevier BASE-Bielefeld Academic Search Engine |
| ISSN: | 1934-5909 1875-9777 |
| DOI: | 10.1016/j.stem.2013.08.012 |
| Popis: | In jawed vertebrates, development of an adaptive immune-system is essential for protection of the born organism against otherwise life-threatening pathogens. Myeloid cells of the innate immune system are formed early in development, whereas lymphopoiesis has been suggested to initiate much later, following emergence of definitive hematopoietic stem cells (HSCs). Herein, we demonstrate that the embryonic lymphoid commitment process initiates earlier than previously appreciated, prior to emergence of definitive HSCs, through establishment of a previously unrecognized entirely immune-restricted and lymphoid-primed progenitor. Notably, this immune-restricted progenitor appears to first emerge in the yolk sac and contributes physiologically to the establishment of lymphoid and some myeloid components of the immune-system, establishing the lymphomyeloid lineage restriction process as an early and physiologically important lineage-commitment step in mammalian hematopoiesis. Copyright © 2013 Elsevier Inc. All rights reserved. |
| Databáze: | OpenAIRE |
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