Data regarding transplant induced germinal center humoral autoimmunity
| Autor: | Reza Motallebzadeh, Manu Chhabra, M. Saeed Qureshi, Martin Goddard, Gavin J. Pettigrew, Christopher A. Devine, Jawaher Alsughayyir, Thomas M. Conlon, Michelle A. Linterman, Jason M. Ali |
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| Přispěvatelé: | Linterman, Michelle [0000-0001-6047-1996], Pettigrew, Gavin [0000-0003-3724-9945], Apollo - University of Cambridge Repository |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adoptive cell transfer
lcsh:Computer applications to medicine. Medical informatics Autoimmune Disease 03 medical and health sciences 0302 clinical medicine Medicine Inflammatory and Immune System lcsh:Science (General) 030304 developmental biology Transplantation 0303 health sciences Multidisciplinary T follicular helper cell differentiation business.industry Autoantibody Germinal center Organ Transplantation Medicine and Dentistry In vitro 3. Good health Endothelial stem cell Haematopoiesis 1107 Immunology Immunology lcsh:R858-859.7 sense organs business 030217 neurology & neurosurgery lcsh:Q1-390 |
| Zdroj: | Data in Brief Data in Brief, Vol 22, Iss, Pp 647-657 (2019) |
| ISSN: | 2352-3409 |
| Popis: | This data is related to the research article entitled “Germinal center humoral autoimmunity independently mediates progression of allograft vasculopathy” (Harper et al., 2016) [2]. The data presented here focuses on the humoral autoimmune response triggered by transferred allogeneic CD4 T cells and includes details on: (a) the recipient splenic germinal center (GC) response; (b) augmentation of humoral autoimmunity and accelerated heart allograft rejection following transplantation from donors primed against recipient; (c) flow cytometric analysis of donor and recipient CD4 T cells for signature markers of T follicular helper cell differentiation; (d) in vitro donor endothelial cell migration in response to column purified autoantibody from recipient sera; (e) analysis of development of humoral responses in recipients following adoptive transfer of donor CD4 T cells and; (f) the development of humoral autoimmunity in mixed haematopoietic chimeric mice. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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