Sparse Activity of Hippocampal Adult-Born Neurons during REM Sleep Is Necessary for Memory Consolidation
| Autor: | Deependra Kumar, Tzong-Shiue Yu, Alvaro Carrier-Ruiz, Pablo Vergara, Sakthivel Srinivasan, Cátia M. Teixeira, Takaaki Ohnishi, Naoko Kaneko, Masafumi Muratani, Toshie Naoi, Kaspar E. Vogt, Iyo Koyanagi, Masashi Yanagisawa, Szu-Han Wang, Kazunobu Sawamoto, Takeshi Sakurai, Masatoshi Kasuya, Masanori Sakaguchi, Masanobu Kano, Yuki Sugaya, Sima Singh, Yoan Cherasse, Steven G. Kernie, Thomas J. McHugh, Pimpimon Nondhalee, Boran A.H. Osman |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Neurogenesis Population Sleep REM Hippocampus Biology Mice 03 medical and health sciences 0302 clinical medicine Conditioning Psychological Animals Learning Sleep and memory Theta Rhythm education Episodic memory Memory Consolidation Neurons education.field_of_study Electromyography General Neuroscience Dentate gyrus Electroencephalography Fear Sleep in non-human animals Optogenetics 030104 developmental biology Dentate Gyrus Calcium Memory consolidation Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Kumar, D, Koyanagi, I, Carrier-Ruiz, A, Vergara, P, Srinivasan, S, Sugaya, Y, Kasuya, M, Yu, T-S, Vogt, K E, Muratani, M, Ohnishi, T, Singh, S, Teixeira, C M, Chérasse, Y, Naoi, T, Wang, S-H, Nondhalee, P, Osman, B A H, Kaneko, N, Sawamoto, K, Kernie, S G, Sakurai, T, McHugh, T J, Kano, M, Yanagisawa, M & Sakaguchi, M 2020, ' Sparse Activity of Hippocampal Adult-Born Neurons during REM Sleep Is Necessary for Memory Consolidation ', Neuron, vol. 107, no. 3, pp. 552-565.E10 . https://doi.org/10.1016/j.neuron.2020.05.008 |
| DOI: | 10.1016/j.neuron.2020.05.008 |
| Popis: | The occurrence of dreaming during rapid eye movement (REM) sleep prompts interest in the role of REM sleep in hippocampal-dependent episodic memory. Within the mammalian hippocampus, the dentate gyrus (DG) has the unique characteristic of exhibiting neurogenesis persisting into adulthood. Despite their small numbers and sparse activity, adult-born neurons (ABNs) in the DG play critical roles in memory; however, their memory function during sleep is unknown. Here, we investigate whether young ABN activity contributes to memory consolidation during sleep using Ca 2+ imaging in freely moving mice. We found that contextual fear learning recruits a population of young ABNs that are reactivated during subsequent REM sleep against a backdrop of overall reduced ABN activity. Optogenetic silencing of this sparse ABN activity during REM sleep alters the structural remodeling of spines on ABN dendrites and impairs memory consolidation. These findings provide a causal link between ABN activity during REM sleep and memory consolidation. |
| Databáze: | OpenAIRE |
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