Development of a New Classification Method for Penile Squamous Cell Carcinoma Based on Lymph Node Density and Standard Pathological Risk Factors: The ND Staging System
| Autor: | Zhuo Wei Liu, Peng Chen, Jie Ping Chen, Chuang Zhong Deng, Qi Wu Mi, Bin Wang, Hui Han, Zai Shang Li, Fang Jian Zhou, Kai Yao, Zi Ke Qin, Yong Hong Li |
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| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Penile Neoplasm 030232 urology & nephrology Urology 03 medical and health sciences 0302 clinical medicine staging system medicine Penile cancer Pathological Lymph node lymph node metastasis business.industry Proportional hazards model Hazard ratio Cancer penile neoplasm medicine.disease Confidence interval Surgery medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis prognosis business lymph node density Research Paper |
| Zdroj: | Journal of Cancer |
| ISSN: | 1837-9664 |
| Popis: | Object: In this study, we evaluated the role of lymph node density (LND) and validated whether LND increases the accuracy of survival prediction when combined with the American Joint Committee on Cancer (AJCC) pathological node (N) staging system for penile cancer (7th edition). Methods: A total of 270 Chinese penile cancer patients treated between March 1999 and October 2014 were retrospectively analyzed. LND was analyzed as a trichotomous variable for the prediction of DSS in this cohort. We developed a new prediction model, which we refer to as the ND staging system, that is based on LND and pathological N staging. The predictive accuracy of this model was further assessed using the concordance index. Results: LND was correlated with the laterality of lymph node metastasis, extranodal extension, pelvic lymph node metastases, and pathologic tumor (T) and N stages (P |
| Databáze: | OpenAIRE |
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