Vitreous levels of soluble vascular endothelial growth factor receptor (VEGFR)-1 in eyes with vitreoretinal diseases
| Autor: | Lloyd Paul Aiello, Yasutaka Mochizuki, Takeshi Kita, Ryo Asato, Ryoichi Arita, Tatsuro Ishibashi, Shuhei Kawahara |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty genetic structures Endothelium Vascular Endothelial Growth Factor Receptor medicine.medical_treatment Enzyme-Linked Immunosorbent Assay Vitrectomy Cellular and Molecular Neuroscience Retinal Diseases Central retinal vein occlusion Ophthalmology medicine Humans Eye Proteins Macular hole Aged Aged 80 and over Retina Diabetic Retinopathy Vascular Endothelial Growth Factor Receptor-1 business.industry Age Factors Diabetic retinopathy Middle Aged medicine.disease eye diseases Sensory Systems Surgery Vitreous Body medicine.anatomical_structure Branch retinal vein occlusion Female Endothelium Vascular sense organs business |
| Zdroj: | British Journal of Ophthalmology. 95:1745-1748 |
| ISSN: | 0007-1161 |
| Popis: | To determine the vitreous levels of soluble vascular endothelial growth factor receptor (sVEGFR)-1 in patients with various vitreoretinal diseases, and to investigate its correlation with patients' age and the activity of proliferative diabetic retinopathy (PDR).Vitreous fluid samples were obtained from 187 eyes of 170 patients who underwent vitrectomy for the treatment of idiopathic macular hole (MH, n=30), branch retinal vein occlusion (BRVO, n=37), central retinal vein occlusion (CRVO, n=27), diabetic macular oedema (DME, n=42) and PDR (n=51). The levels of sVEGFR-1 in the vitreous were measured by ELISA.The levels of sVEGFR-1 (pg/ml) were not significantly different among each disease examined (MH 3900.1 ± 1188.9, BRVO 3969.7 ± 1741.6, CRVO 4897.7 ± 1717.7, DME 3856.21 ± 1374.7, PDR 4212.3 ± 1474.9). There was a significant positive correlation between vitreous concentrations of sVEGFR-1 and patients' age (r=0.430, p0.01). The sVEGFR-1 concentration in subjects with active PDR was significantly lower than in those with quiescent PDR (p0.0001), even after being adjusted for age (p0.0001).Vitreous concentrations of sVEGFR-1 increase with advancing age and are associated with quiescent rather than active PDR even after adjustment for age. |
| Databáze: | OpenAIRE |
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