Agrp, a novel gene implicated in the control of feeding

Autor:	Kevin Lee Stark
Rok vydání:	1998
Předmět:	Pharmacology medicine.medical_specialty digestive oral and skin physiology Mutant Endogeny General Medicine Biology Biochemical Activity Phenotype Melanocortin 3 receptor Cell biology Endocrinology Internal medicine medicine Pharmacology (medical) Melanocortin Receptor Gene
Zdroj:	Expert Opinion on Investigational Drugs. 7:859-864
ISSN:	1744-7658 1354-3784
DOI:	10.1517/13543784.7.6.859
Popis:	Rapid progress has recently been made to characterise a new pathway involved in the control of feeding behaviour, referred to as the melanocortinergic pathway. Studies of the obese phenotype of the yellow mouse mutant (Ay) suggested the existence of this feeding circuit for some time, but the precise molecular and biochemical regulation was unclear. Through pharmacological and genetic approaches, specific melanocortin receptors expressed within the brain are now known to play a pivotal role. Since receptor agonists decrease food intake, and blocking receptor activity (through antagonists or mutations) increases food intake, this pathway is thought to provide a tonic inhibitory effect on food consumption. A unique feature of this pathway seems to be the regulation of receptor activity by an endogenous protein antagonist, agouti-related protein (AGRP). The molecular characterisation and biochemical activity of this gene suggest that it plays a role in the regulation of feeding behaviour.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbd98e44257e46696fd392d2fd2912ac https://doi.org/10.1517/13543784.7.6.859 Zobrazit plný text záznamu