Flavonol Caffeoylglycosides as alpha-Glucosidase Inhibitors from Spiraea cantoniensis Flower
| Autor: | Jun Kawabata, Atsuyuki Hishida, Kaori Yoshida, Osamu Iida, Keizo Hosokawa |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Glycoside Hydrolase Inhibitors
Flavonols Flavonoid Flowers Biology chemistry.chemical_compound Caffeic Acids Animals Glycosides Enzyme Inhibitors Spiraea cantoniensis chemistry.chemical_classification General Chemistry Enzyme assay Rats Intestines chemistry Biochemistry Polyphenol biology.protein General Agricultural and Biological Sciences Kaempferol Quercetin Maltase Spiraea Sucrase |
| Zdroj: | Journal of agricultural and food chemistry. 56(12) |
| ISSN: | 1520-5118 |
| Popis: | In the screening experiments for rat intestinal alpha-glucosidase inhibitors in 218 plants cultivated in the Japanese temperate region, potent maltase-inhibiting activity was found in the extract of flowers of Spiraea cantoniensis. The enzyme assay guided fractionation of the extract led to the isolation of three flavonol caffeoylglycosides, quercetin 3- O-(6- O-caffeoyl)-beta-galactoside ( 1), kaempferol 3- O-(6- O-caffeoyl)-beta-galactoside ( 2), and kaempferol 3- O-(6- O-caffeoyl)-beta-glucoside ( 3), as rat intestinal maltase inhibitors. This is the first report on the alpha-glucosidase-inhibitory activity of those flavonol caffeoylglycosides. Comparison in the activity of the isolates indicated the importance of caffeoyl substructures in the molecule for the alpha-glucosidase-inhibiting activity. The relatively high contents of the active isolates in the plant suggest that S. cantoniensis could be physiologically useful for treatment of diabetes. |
| Databáze: | OpenAIRE |
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