Baboons undergoing orthotopic concordant cardiac xenotransplantation surviving more than 300 days: Effect of immunosuppressive regimen
| Autor: | Steven R. Gundry, Hironori Izutani, Leonard L. Bailey, Sandra Nehlsen Cannarella, Miki Asano, Omar R. Fagoaga |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Graft Rejection
Pulmonary and Respiratory Medicine medicine.medical_specialty Time Factors medicine.medical_treatment Transplantation Heterologous Splenectomy Infections Gastroenterology Tacrolimus Actuarial Analysis Internal medicine medicine Animals Antilymphocyte Serum Bone Marrow Transplantation Immunosuppression Therapy Chemotherapy business.industry Immunotherapy Ciclosporin Macaca mulatta Surgery Transplantation Regimen Methotrexate Cyclosporine Heart Transplantation Cardiology and Cardiovascular Medicine Complication business Immunosuppressive Agents Papio medicine.drug |
| Zdroj: | The Journal of Thoracic and Cardiovascular Surgery. 125:60-70 |
| ISSN: | 0022-5223 |
| DOI: | 10.1067/mtc.2003.89 |
| Popis: | Objective: We reviewed long-term survival among hosts in 3 consecutive series of a rhesus monkey-baboon orthotopic cardiac xenotransplantation model with reference to host immune response, including the effectiveness in preventing rejection and limiting toxicity concerning infection, to evaluate specific immunosuppressive regimens for long-term outcomes. Methods: Six juvenile baboons surviving more than 300 days after transplantation were reviewed. Regimen A consisted of splenectomy, FK506, methotrexate, and antilymphocyte globulin. Regimen B consisted of pretransplantation and chronic maintenance with cyclosporine A (INN: ciclosporin), methotrexate, and antithymocyte globulin. Regimen C was the same as regimen B plus pretransplantation total lymphoid irradiation and intraoperative donor bone marrow cell infusion. Rejections were detected by means of echocardiography. Results: Long-term survivors in 3 groups were followed for a range of 332 to 515 days (mean, 436 days). Rejection frequency in regimens A, B, and C was 0.35, 0.58, and 0.18 per month, and rescue therapy days were 23 (4.8%), 123 (9.5%), and 20 (2.4%), respectively (P |
| Databáze: | OpenAIRE |
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