Validation of MRI quantitative susceptibility mapping of superparamagnetic iron oxide nanoparticles for hyperthermia applications in live subjects

Autor: Kelly M. Gillen, Padraic O' Malley, Ju-Young Kim, Yogindra Vedvyas, Zhe Liu, Richard K. Lee, Kofi Deh, Dina Bedretdinova, Yi Wang, Pascal Spincemaille, Moonsoo M. Jin, Marjan Zaman, Thanh D. Nguyen
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Hyperthermia
Male
Superparamagnetic iron oxide nanoparticles
Cancer therapy
Contrast Media
lcsh:Medicine
Therapeutics
Adenocarcinoma
Ferric Compounds
Article
030218 nuclear medicine & medical imaging
03 medical and health sciences
Mice
0302 clinical medicine
Targeted therapies
Subcutaneous Tissue
Mice
Inbred NOD
Cell Line
Tumor
Positron Emission Tomography Computed Tomography
Injection site
medicine
Image Processing
Computer-Assisted
Distribution (pharmacology)
Animals
Tissue Distribution
lcsh:Science
Radioisotopes
Multidisciplinary
Chemistry
lcsh:R
Prostatic Neoplasms
Quantitative susceptibility mapping
Hyperthermia
Induced
medicine.disease
Magnetic Resonance Imaging
Xenograft Model Antitumor Assays
Ferrosoferric Oxide
Tumor Burden
Ferumoxytol
Heat generation
Nanoparticles
lcsh:Q
Zirconium
Radiopharmaceuticals
Biomedical engineering
030217 neurology & neurosurgery
Zdroj: Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
ISSN: 2045-2322
Popis: The use of magnetic fluid hyperthermia (MFH) for cancer therapy has shown promise but lacks suitable methods for quantifying exogenous irons such as superparamagnetic iron oxide (SPIO) nanoparticles as a source of heat generation under an alternating magnetic field (AMF). Application of quantitative susceptibility mapping (QSM) technique to prediction of SPIO in preclinical models has been challenging due to a large variation of susceptibility values, chemical shift from tissue fat, and noisier data arising from the higher resolution required to visualize the anatomy of small animals. In this study, we developed a robust QSM for the SPIO ferumoxytol in live mice to examine its potential application in MFH for cancer therapy. We demonstrated that QSM was able to simultaneously detect high level ferumoxytol accumulation in the liver and low level localization near the periphery of tumors. Detection of ferumoxytol distribution in the body by QSM, however, required imaging prior to and post ferumoxytol injection to discriminate exogenous iron susceptibility from other endogenous sources. Intratumoral injection of ferumoxytol combined with AMF produced a ferumoxytol-dose dependent tumor killing. Histology of tumor sections corroborated QSM visualization of ferumoxytol distribution near the tumor periphery, and confirmed the spatial correlation of cell death with ferumoxytol distribution. Due to the dissipation of SPIOs from the injection site, quantitative mapping of SPIO distribution will aid in estimating a change in temperature in tissues, thereby maximizing MFH effects on tumors and minimizing side-effects by avoiding unwanted tissue heating.
Databáze: OpenAIRE
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