Strategic pooling of compounds for high-throughput screening
| Autor: | Luke Miller, Brian Hudson, Rob Lifely, Michael M. Hann, Xiao Qing Lewell, Nigel Grahame Ramsden |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Computer science
High-throughput screening Pooling Drug Evaluation Preclinical General Chemistry Combinatorial chemistry Biological Testing Mass Spectrometry Computer Science Applications Structure-Activity Relationship Computational Theory and Mathematics Order (exchange) Drug Design Biochemical engineering Information Systems Chromatography Liquid |
| Zdroj: | Journal of chemical information and computer sciences. 39(5) |
| ISSN: | 0095-2338 |
| Popis: | Bringing new medicines to the market depends on the rapid discovery of new and effective drugs, often initiated through the biological testing of many thousands of compounds in high-throughput screening (HTS). Mixing compounds together into pools for screening is one way to accelerate this process and reduce costs. This paper contains both theoretical and experimental data which suggest that careful selection of compounds to be pooled together is necessary in order to reduce the risk of reactivity between compounds within the pools. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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