Measuring and realizing the translational significance of preclinical in vivo studies of painful osteoarthritis
| Autor: | G.T. Whiteside, M. Hummel |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Pathology
medicine.medical_specialty Endpoint Determination Population Biomedical Engineering Osteoarthritis Key issues Translational Research Biomedical 03 medical and health sciences 0302 clinical medicine Animal model Rheumatology medicine Animals Humans Orthopedics and Sports Medicine Intensive care medicine education 030203 arthritis & rheumatology education.field_of_study business.industry medicine.disease Bench to bedside Disease Models Animal Treatment Outcome Data Interpretation Statistical business 030217 neurology & neurosurgery |
| Zdroj: | Osteoarthritis and cartilage. 25(3) |
| ISSN: | 1522-9653 |
| Popis: | In this communication, we discuss some key issues surrounding the translation of preclinical efficacy studies in models of painful osteoarthritis (OA) to the clinical arena. We highlight potential pitfalls which could negatively impact successful translation. These include lack of alignment between a model + endpoint and the intended clinical population, employing testing strategies in animals that are not appropriate for the targeted human population such as pre-emptive treatment and lastly, underestimating the magnitude of the efficacy signal in animals that may be needed to see an effect in the clinical population. Through careful analysis, we highlight the importance of each pitfall by providing relevant examples that will hopefully improve future chances of optimizing translation in the area of OA pain research. We advocate advancing publications directed at comparing methods, outcomes and conclusions between preclinical and clinical studies, regardless of whether the findings are positive or negative, are important for improving the potential for a desired successful translation from the bench to bedside. |
| Databáze: | OpenAIRE |
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