Bariatric surgery emphasizes biological sex differences in rodent hepatic lipid handling
| Autor: | Darleen A. Sandoval, Bernadette E. Grayson, Michelle R. Adams, Rebekah Karns, Joyce Sorrell, Randy J. Seeley, Ruth Gutierrez-Aguilar, Emily K. Matter, Philip N. Howles |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Rodent medicine.medical_treatment Gene Expression 030209 endocrinology & metabolism Gender Studies 03 medical and health sciences 0302 clinical medicine Endocrinology Weight loss Gastrectomy biology.animal parasitic diseases Weight Loss medicine Animals Rats Long-Evans Triglycerides Bariatric surgery Sex Characteristics biology business.industry Research Lipid metabolism Human physiology Biological sex Sex difference Lipid Metabolism 3. Good health Surgery Liver Hepatic lipid 030211 gastroenterology & hepatology Female Vertical sleeve gastrectomy medicine.symptom business Sex characteristics |
| Zdroj: | Biology of Sex Differences |
| ISSN: | 2042-6410 |
| Popis: | Background Eighty percent of patients who receive bariatric surgery are women, yet the majority of preclinical studies are in male rodents. Because sex differences drive hepatic gene expression and overall lipid metabolism, we sought to determine whether sex differences were also apparent in these endpoints in response to bariatric surgery. Methods Two cohorts of age-matched virgin male and female Long-Evans rats were placed on a high fat diet for 3 weeks and then received either Sham or vertical sleeve gastrectomy (VSG), a surgery which resects 80% of the stomach with no intestinal rearrangement. Results Each sex exhibited significantly decreased body weight due to a reduction in fat mass relative to Sham controls (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|