Pancreatic duct lavage cytology with the cell block method for discriminating benign and malignant branch-duct type intraductal papillary mucinous neoplasms
| Autor: | Yuuji Matsumura, Jin Kan Sai, Bunsei Nobukawa, Sumio Watanabe |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Cytodiagnosis H&E stain Therapeutic irrigation Single Center Gastroenterology Endosonography Branch Duct Predictive Value of Tests Internal medicine Cytology medicine Humans Radiology Nuclear Medicine and imaging Endoscopy Digestive System Therapeutic Irrigation Aged Pancreatic duct business.industry Mucins Pancreatic Ducts Cancer Middle Aged medicine.disease Immunohistochemistry Pancreatic Neoplasms medicine.anatomical_structure Predictive value of tests Female Neoplasms Cystic Mucinous and Serous business |
| Zdroj: | Gastrointestinal Endoscopy. 77:726-735 |
| ISSN: | 0016-5107 |
| DOI: | 10.1016/j.gie.2012.11.008 |
| Popis: | Background Differentiation between benign and malignant branch-duct type intraductal papillary mucinous neoplasms (IPMNs) remains challenging. Objective To examine the usefulness of pancreatic duct lavage cytology with cell block method for discriminating benign and malignant branch-duct type IPMNs. Patients and Methods Between December 2007 and April 2011, patients with branch-duct type IPMNs having mural nodules on EUS were examined by pancreatic duct lavage cytology by using the cell block method. Cell block sections underwent hematoxylin and eosin staining and mucin immunostainings (MUCs 1, 2, 5AC, and 6). Design Single-center, prospective study. Setting Academic medical center. Main Outcome Measurements The sensitivity and specificity of cytology were assessed. The agreement between cytological and histological results for MUC was also examined. Results Cytology with this method was investigated in 44 patients. Cell block diagnosis was cancer positive (class V or IV) in 11 patients and negative (classes I, II, III, and noninformative) in 33. The sensitivity, specificity, and positive and negative predictive values of this method were 92%, 100%, 100%, and 97%, respectively. The cytological and histological results of MUCs 1, 2, 5AC, and 6 agreed in 88% (15/17), 94% (16/17), 88% (15/17), and 100% (17/17), respectively. Limitations Single center and small number of patients. Conclusions Pancreatic duct lavage cytology with the cell block method may be useful to differentiate between benign and malignant IPMNs preoperatively and as well as to determine their mucin type. |
| Databáze: | OpenAIRE |
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