Patient characteristics in Behçet’s Syndrome and their associations with major organ involvement: a single-centre experience of 2118 cases
| Autor: | Tahsin Murat Turgay, Abk Dinçer, Murat Torgutalp, R Yılmaz, Ega Gülöksüz, Serdar Sezer, G Karataş, Mehmet Levent Yüksel, E M Özel, Didem Sahin Eroglu, Müçteba Enes Yayla, Aşkın Ateş, Gülay Kinikli |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty viruses Immunology Logistic regression Ordinal regression 03 medical and health sciences 0302 clinical medicine Rheumatology Internal medicine medicine Humans Immunology and Allergy Sex organ 030212 general & internal medicine Ulcer Aged Retrospective Studies 030203 arthritis & rheumatology S syndrome business.industry Behcet Syndrome Medical record General Medicine biochemical phenomena metabolism and nutrition Genital ulcer Logistic Models Organ involvement Female Ordered logit medicine.symptom business |
| Zdroj: | Scandinavian Journal of Rheumatology. 51:50-58 |
| ISSN: | 1502-7732 0300-9742 |
| DOI: | 10.1080/03009742.2021.1904622 |
| Popis: | Objectives: To evaluate the demographic and clinical characteristics of patients with Behcet's syndrome (BS), and to define their associations with the presence of major organ involvement (MOI).Method: Medical records of 2118 patients (964 males, 1154 females) were analysed retrospectively. MOI was defined as the presence of at least one of vascular, eye, nervous, or gastrointestinal system involvement. Univariable and multivariable binary and ordinal logistic regression analyses were applied to assess the factors that were potentially associated with MOI.Results: The mean ± sd age at diagnosis was 30.5 ± 9.4 years. Genital ulcer and joint involvement were more common in females (both p < 0.001), while MOI was more frequent in males (p < 0.001). Genital ulcer (p < 0.001) and vascular involvement (p = 0.006) were more common in patients with a younger age at diagnosis, while joint involvement was more common in older patients. A total of 1097 patients (51.8%) had at least one MOI, 322 (15.2%) at least two MOIs, and 48 (2.3%) at least three MOIs. Male gender, smoking history, and absence of genital ulcer were significantly associated with MOI in multivariable binary logistic regression. Multivariable ordinal regression analyses confirmed the association between MOI and male gender and smoking, but not the protective effect of genital ulcers. In both regression analyses, we found no significant effects of age, human leucocyte antigen-B51, skin involvement, or joint involvement on MOI.Conclusion: Male gender and positive smoking history have a significant influence on the presence of MOI in patients with BS. |
| Databáze: | OpenAIRE |
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