Association between Serum Uric Acid Levels, Nutritional and Antioxidant Status in Patients on Hemodialysis
| Autor: | Francisco Bueno-Hernández, Ángeles Espinosa-Cuevas, Omar Noel Medina-Campos, Ana Laura López-Santos, Etna Dominguez-Zambrano, Cristino Cruz-Rivera, José Pedraza-Chaverri |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male malondialdehyde medicine.medical_specialty Oxygen radical absorbance capacity medicine.medical_treatment Population 030232 urology & nephrology lcsh:TX341-641 030204 cardiovascular system & hematology urologic and male genital diseases Gastroenterology Article Antioxidants 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine uric acid Internal medicine medicine Humans oxidative stress Hyperuricemia education education.field_of_study Creatinine Nutrition and Dietetics business.industry nutritional and metabolic diseases 2 2-diphenyl-1-picrilhydrazyl Middle Aged medicine.disease Malondialdehyde nutritional status oxygen radical absorbance capacity Cross-Sectional Studies chemistry renal dialysis Uric acid Female Trolox Hemodialysis business lcsh:Nutrition. Foods and food supply Food Science |
| Zdroj: | Nutrients, Vol 12, Iss 2600, p 2600 (2020) Nutrients Volume 12 Issue 9 |
| ISSN: | 2072-6643 |
| Popis: | Purpose: To determine the relationship between uric acid (UA) and nutritional and antioxidant status in hemodialysis (HD) patients, given that hyperuricemia could be an indicator of good nutritional status possibly because of the antioxidant properties of UA. Methods: Cross-sectional study with 93 patients on HD. Hyperuricemia was considered as UA &ge 6.0 mg/dL in females and &ge 7.0 mg/dL in males. Nutritional variables were registered. Blood samples were taken before the dialysis session to determine oxidative damage as plasma malondialdehyde (MDA) content, and antioxidant capacity measuring 2,2-diphenyl-piclrylhidrazil radical (DPPH●) scavenging activity and oxygen radical absorbance capacity (ORAC) value. Results: Patients with hyperuricemia had higher creatinine (11.9 vs. 10.5 mg/dL p = 0.004), potassium (5.5 vs. 5.0 mg/dL p = 0.014) levels phase angle (5.8 vs. 4.9 p = 0.005), protein consumption (normalized protein nitrogen appearance, nPNA, 1.03 vs. 0.83 p = 0.013) than normouricemic patients. DPPH● scavenging activity was higher in hyperuricemic subjects (1.139 vs. 1.049 mM Trolox equivalents p = 0.007) likewise, hyperuricemic subjects had less oxidant damage measured by MDA (10.6 vs. 12.7 nmol/mL p = 0.020). Subjects with normouricemia were at higher risk of having a reactance to height (Xc/H) ratio less than 35 (OR 2.79 95% CI, 1.1&ndash 7.017, p = 0.028) nPNA < 1.0 (OR 3.78 95% CI, 1.4&ndash 10.2, p = 0.007), diagnosis of cachexia (OR 2.95 95% CI, 1156&ndash 7.518, p = 0.021), potassium levels < 5 (OR 2.97 95% CI, 1.136&ndash 7.772, p = 0.023) and PA < 5.5° (OR 3.38 95% CI, 1.309&ndash 8.749, p = 0.012.) Conclusions: Patients with hyperuricemia had higher antioxidant capacity and better nutritional status. Purines and protein restrictions in HD patients with hyperuricemia need to be reviewed individually for each patient. More studies are needed to stablish a cut point of UA levels in renal population. |
| Databáze: | OpenAIRE |
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