Does influenza pandemic preparedness and mitigation require gain-of-function research?

Autor:	Matthew Scotch, Daniel Magee, Chau Minh Bui, Dillon C Adam, C. Raina MacIntyre
Rok vydání:	2017
Předmět:	0301 basic medicine Pulmonary and Respiratory Medicine Biomedical Research Epidemiology 030106 microbiology Biosecurity pandemics medicine.disease_cause 03 medical and health sciences Public health surveillance Environmental health Influenza Human Pandemic medicine Humans Expert Commentary business.industry Public Health Environmental and Occupational Health Influenza a Influenza pandemic Virology public health surveillance Influenza A virus subtype H5N1 3. Good health 030104 developmental biology Infectious Diseases Gain of function Influenza A virus Preparedness Receptors Virus influenza business
Zdroj:	Influenza and Other Respiratory Viruses
ISSN:	1750-2640
DOI:	10.1111/irv.12458
Popis:	The risk and benefits of gain‐of‐function studies on influenza A have been widely debated since 2012 when the methods to create two respiratory transmissible H5N1 mutant isolates were published. Opponents of gain‐of‐function studies argue the biosecurity risk is unacceptable, while proponents cite potential uses for pandemic surveillance, preparedness and mitigation. In this commentary, we provide an overview of the background and applications of gain‐of‐function research and argue that the anticipated benefits have yet to materialize while the significant risks remain.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbceb62b3cb5479632ae7e61656fadbb https://doi.org/10.1111/irv.12458 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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