Spaceflight alters immune cell function and distribution
| Autor: | A. T. Lesnyak, G. R. Taylor, B. B. Fuchs, A. D. Mandel, W. D. Berry, Gerald Sonnenfeld, A. L. Rakhmilevich, I. V. Konstantinova |
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| Rok vydání: | 1992 |
| Předmět: |
Male
Physiology T-Lymphocytes Population Biology Granulocyte Spaceflight law.invention Andrology Myelogenous Immune system Bone Marrow law Physiology (medical) medicine Animals education B-Lymphocytes Immunity Cellular education.field_of_study Monocyte Granulocyte-Macrophage Colony-Stimulating Factor Rats Inbred Strains Receptors Interleukin-2 Space Flight Rats Killer Cells Natural Phenotype Granulocyte macrophage colony-stimulating factor medicine.anatomical_structure Antigens Surface Immunology Bone marrow Spleen medicine.drug |
| Zdroj: | Journal of Applied Physiology. 73:S191-S195 |
| ISSN: | 1522-1601 8750-7587 |
| DOI: | 10.1152/jappl.1992.73.2.s191 |
| Popis: | Experiments were carried out aboard COSMOS 2044 to determine the effects of spaceflight on immunologically important cell function and distribution. Control groups included vivarium, synchronous, and antiorthostatically suspended rats. In one experiment, rat bone marrow cells were examined in Moscow, for their response to recombinant murine granulocyte/monocyte colony-stimulating factor (GM-CSF). In another experiment, rat spleen and bone marrow cells were stained in Moscow with a variety of antibodies directed against cell surface antigenic markers. These cells were preserved and shipped to the United States for analysis on a flow cytometer. Bone marrow cells from flown and suspended rats showed a decreased response to granulocyte/monocyte colony-stimulating factor compared with bone marrow cells from control rats. Of the spleen cell subpopulations examined from flown rats, only those cells expressing markers for suppressor-cytotoxic T- and helper T-cells showed an increased percentage of stained cells. Bone marrow cells showed an increase in the percentage of cells expressing markers for helper T-cells in the myelogenous population and increased percentages of anti-asialo granulocyte/monocyte-1-bearing interleukin-2 receptor-bearing pan T- and helper T-cells in the lymphocytic population. Cell populations from rats suspended antiorthostatically did not follow the same pattern of distribution of leukocytes as cell populations for flown rats. The results from COSMOS 2044 are similar, but not identical, to earlier results from COSMOS 1887 and confirm that spaceflight can have profound effects on immune system components and activities. |
| Databáze: | OpenAIRE |
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