Risk of Death in Nursing Home Residents After COVID-19 Vaccination

Autor: Fenne Wouters, Anouk M. van Loon, Jeanine J.S. Rutten, Martin Smalbrugge, Cees M.P.M. Hertogh, Karlijn J. Joling
Přispěvatelé: Elderly care medicine, APH - Aging & Later Life, APH - Quality of Care, APH - Mental Health, APH - Methodology, APH - Digital Health
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Journal of the American Medical Directors Association, 23(10), 1750-1753.e2. Elsevier Inc.
Wouters, F, van Loon, A M, Rutten, J J S, Smalbrugge, M, Hertogh, C M P M & Joling, K J 2022, ' Risk of Death in Nursing Home Residents After COVID-19 Vaccination ', Journal of the American Medical Directors Association, vol. 23, no. 10, pp. 1750-1753.e2 . https://doi.org/10.1016/j.jamda.2022.08.013
ISSN: 1525-8610
DOI: 10.1016/j.jamda.2022.08.013
Popis: Objectives: In the first months of 2021, the Dutch COVID-19 vaccination campaign was disturbed by reports of death in Norwegian nursing homes (NHs) after vaccination. Reports predominantly concerned persons >65 years of age with 1 or more comorbidities. Also, in the Netherlands adverse events were reported after COVID-19 vaccination in this vulnerable group. Yet, it was unclear whether a causal link between vaccination and death existed. Therefore, we investigated the risk of death after COVID-19 vaccination in Dutch NH residents compared with the risk of death in NH residents prior to the COVID-19 pandemic. Design: Population-based longitudinal cohort study with electronic health record data. Setting and Participants: We studied Dutch NH residents from 73 NHs who received 1 or 2 COVID-19 vaccination(s) between January 13 and April 16, 2021 (n = 21,762). As a historical comparison group, we included Dutch NH residents who were registered in the same period in 2019 (n = 27,591). Methods: Data on vaccination status, age, gender, type of care, comorbidities, and date of NH entry and (if applicable) discharge or date of death were extracted from electronic health records. Risk of death after 30 days was evaluated and compared between vaccinated residents and historical comparison residents with Kaplan-Meier and Cox regression analyses. Regression analyses were adjusted for age, gender, comorbidities, and length of stay. Results: Risk of death in NH residents after one COVID-19 vaccination (regardless of whether a second vaccination was given) was decreased compared with historical comparison residents from 2019 (adjusted HR 0.77, 95% CI 0.69-0.86). The risk of death further decreased after 2 vaccinations compared with the historical comparison group (adjusted HR 0.57, 95% CI 0.50-0.64). Conclusions and Implications: We found no indication that risk of death in NH residents is increased after COVID-19 vaccination. These results indicate that COVID-19 vaccination in NH residents is safe and could reduce fear and resistance toward vaccination.
Databáze: OpenAIRE
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