Incidence of and risk factors for totally implantable vascular access device complications in patients with gastric cancer: A retrospective analysis

Autor:	Tomoharu Miyashita, Jun Kinoshita, Hidehiro Tajima, Katsunobu Oyama, Hiroyuki Takamura, Itasu Ninomiya, Tetsuo Ohta, Mitsuyoshi Okazaki, Sachio Fushida
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	Cancer Research medicine.medical_specialty Deep vein 03 medical and health sciences 0302 clinical medicine catheter-related deep vein thrombosis Vascular Access Device Complications medicine infectious adverse events business.industry Incidence (epidemiology) gastric cancer totally implantable vascular access devices Cancer Retrospective cohort study Odds ratio Articles long-term complications medicine.disease Thrombosis Surgery medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology business Body mass index
Zdroj:	Molecular and Clinical Oncology
ISSN:	2049-9469 2049-9450
Popis:	Totally implantable vascular access devices (TIVADs) are often used to administer chemotherapy by prolonged intravenous infusion. The objective of the present study was to investigate the incidence of long-term complications and identify risk factors associated with TIVAD placement in patients with gastric cancer. A total of 121 patients with gastric cancer who had undergone 150 TIVAD placement procedures for chemotherapy or supportive care were enrolled in the present retrospective cohort study. A number of risk factors were analyzed, including age, sex, hypertension, diabetes mellitus, history of thrombosis, body mass index, disease stage, and site and purpose of TIVAD. In total, 40 TIVADs (26.7%) developed long-term complications, of which 27 (18.0%) were infections, seven (4.7%) were catheter-related deep vein thrombosis (CR-DVT), and six (4.0%) were obstructions. Chemotherapy was associated with an increased rate of infectious adverse events (odds ratio 2.925; 95% CI, 1.104-7.750; P=0.031) according to the multivariate analysis. CR-DVT occurred more frequently in upper arm ports than in chest wall ports; however, this difference was not statistically significant (7.5 vs. 0.0%; P=0.084) according to the univariable analysis. All CR-DVTs developed in the upper arm sites. Chemotherapy and the upper arm site were associated with long-term complications in patients with TIVAD. However, further studies are needed to confirm the findings of the present study and to determine the reasons for the high incidence of long-term complications in these patients.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbcc9a48b79e0c4be662e4bb786e0c1c http://europepmc.org/articles/PMC6713938 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.