The Emerging Role of miRNAs and Their Clinical Implication in Biliary Tract Cancer
| Autor: | Amanda Braga Bona, Marília de Arruda Cardoso Smith, Danielle Queiroz Calcagno, Paulo Pimentel Assumpção, Kelly Cristina da Silva Oliveira, Nina Nayara Ferreira Martins, Rommel Rodríguez Burbano, Geraldo Ishak |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Biliary tract cancer Hepatology business.industry Gastroenterology Review Article medicine.disease Bioinformatics 03 medical and health sciences Circulating MicroRNA 030104 developmental biology 0302 clinical medicine Biliary tract 030220 oncology & carcinogenesis Potential biomarkers microRNA medicine lcsh:Diseases of the digestive system. Gastroenterology Cancer development Radical surgery Gallbladder cancer lcsh:RC799-869 business |
| Zdroj: | Gastroenterology Research and Practice Gastroenterology Research and Practice, Vol 2016 (2016) |
| ISSN: | 1687-6121 |
| Popis: | Biliary tract cancers are aggressive malignancies that include gallbladder cancer and tumors of intra- and extrahepatic ducts and have a poor prognosis. Surgical resection remains the main curative therapy. Nevertheless, numerous patients experience recurrence even after radical surgery. This scenario drives the research to identify biliary tract cancer biomarkers despite the limited progress that has been made. Recently, a large number of studies have demonstrated that deregulated expression of microRNAs is closely associated with cancer development and progression. In this review, we highlight the role and importance of microRNAs in biliary tract cancers with an emphasis on utilizing circulating microRNAs as potential biomarkers. Additionally, we report several single-nucleotide polymorphisms inmicroRNAgenes that are associated with the susceptibility of biliary tract tumors. |
| Databáze: | OpenAIRE |
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