Evaluation of urine pneumococcal antigen test performance among adults in Western Kenya
| Autor: | Fabiana Cristina Pimenta, Cynthia G. Whitney, Robert F. Breiman, Maria da Gloria Carvalho, Geofrey Jagero, Lee M. Hampton, Muthoni Junghae, Godfrey Bigogo, Daniel R. Feikin, Laura Conklin |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine Microbiology (medical) medicine.medical_specialty Adolescent 030106 microbiology Urine medicine.disease_cause Sensitivity and Specificity Pneumococcal Infections Article Young Adult 03 medical and health sciences 0302 clinical medicine Antigen Internal medicine Streptococcus pneumoniae medicine Humans 030212 general & internal medicine Antigens Respiratory system Aged Aged 80 and over Immunoassay Antigens Bacterial Diagnostic Tests Routine business.industry General Medicine Middle Aged Kenya Confidence interval Infectious Diseases Pneumococcal antigen Africa Immunology Female Test performance Hiv status business |
| Zdroj: | Diagn Microbiol Infect Dis |
| ISSN: | 0732-8893 |
| Popis: | When used in an area of rural western Kenya, the BinaxNOW® urine antigen test had a sensitivity of 67% (95% Confidence Interval [CI]: 43–85%) among 21 adults ≥15 years old with acute respiratory illnesses and pneumococcal bacteremia and a specificity of 98% (95% CI: 96–99%) among 660 adults ≥15 years old without fever or cough. The specificity of the test was not significantly affected by pneumococcal colonization, regardless of patients’ HIV status, age, or sex. Use of the pneumococcal urine antigen test in clinical assessments of adults in Africa with acute respiratory illness is a viable option regardless of whether a patient is colonized by pneumococci, even among HIV-infected adults, although the moderate sensitivity of the urine antigen test indicates that the test is probably best used clinically as part of a panel with other tests that can detect pneumococci. |
| Databáze: | OpenAIRE |
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