Bone remodeling alterations in myelodysplastic syndrome
| Autor: | Xavier Nogués, Robert R. Recker, A. Diez, Leonardo Mellibovsky, M. L. Mariñoso, Encarna Perez-Vila, Sergi Serrano, J. Aubia |
|---|---|
| Předmět: |
Blood Platelets
Male medicine.medical_specialty Pathology Histology Physiology Endocrinology Diabetes and Metabolism Osteoclasts Bone Marrow Cells Cell Count Bone remodeling Ilium Osteoclast Bone Marrow Internal medicine Bone cell medicine Leukocytes Humans Aged Analysis of Variance Bone Development Osteoblasts biology Chemistry Osteoid Osteoblast Middle Aged Tetracycline Hematopoiesis Apposition medicine.anatomical_structure Endocrinology Myelodysplastic Syndromes Osteocalcin biology.protein Female Bone marrow Bone Remodeling Biomarkers |
| Zdroj: | Europe PubMed Central |
| Popis: | There is a close relationship between hematopoietic bone marrow and bone cells. Thus, the profound derangement of hematopoiesis in myelodysplastic syndromes (MDS) might be expected to affect bone cell function. We studied the dynamic histomorphometric changes in bone in 22 MDS patients to examine this relationship and analyze the influence of hematological disease on bone remodeling. Bone-regulating hormones and histomorphometry of undecalcified transiliac bone biopsies, after double tetracycline labeling, were studied. Serum calcium, phosphorus, creatinine, alkaline phophatase, osteocalcin, iPTH, 25(OH)D3, 1,25(OH)2D3, hydroxyprolinuria, and calcium/creatinine ratio in urine were normal compared with controls. Histomorphometry showed a significant decrease in osteoblast surface (Ob.S/BS) (0.30 +/- 0.40 vs. 0.8 +/- 1.1, p = 0.031), wall thickness (W.Th), (22.03 +/- 5.5 vs. 31.8 +/- 5.8, p < 0.005), osteoclast number (N.Oc/T.Ar) (0.004 +/- 0.01 vs. 0.017 +/- 0.01, p = 0.03), mineral apposition rate (MAR) (0.16 +/- 0.15 vs. 0.53 +/- 0.19, p < 0.005), bone formation rate, surface referent (BFR/BS) (0.004 +/- 0.10 vs. 0.016 +/- 0.016, p = 0.009), and activation frequency (Ac.f) (0.06 +/- 0.07 vs. 0.21 +/- 0.23, p = 0.008). An increase in mineralization lag time (MLT) (119.2 +/- 78.6 vs. 29.6 +/- 77, p < 0.005), (mean +/- SD, unpaired Student t-test) was observed. Bone volume (BV/ TV), eroded surfaces (ES/BS), and osteoid thickness (O.Th) remained unchanged. This picture of adynamic bone with decreased mineral apposition rate and markedly decreased osteoclast number is a characteristic finding in MDS patients. Thus, bone histomorphometric finding in MDS patients show the relationships and interactions between hematopoietic and bone cells. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|