Evaluation of Clinical and Pathological Factors to Predict High Risk of Recurrence in Patients With Stage II Colon Cancer
| Autor: | Jonathan M. Loree, Yaling Yin, Brent Parker, Winson Y. Cheung, Janine M. Davies, Breanne Cadham, Sharlene Gill |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Oncology
medicine.medical_specialty Multivariate analysis Colorectal cancer Population Risk Factors Internal medicine medicine Humans In patient education Pathological Neoplasm Staging education.field_of_study biology business.industry Gastroenterology Prognosis medicine.disease Transthyretin Time to recurrence Colonic Neoplasms biology.protein Neoplasm Recurrence Local business Stage ii colon cancer |
| Zdroj: | Clinical Colorectal Cancer. 21:e39-e48 |
| ISSN: | 1533-0028 |
| DOI: | 10.1016/j.clcc.2021.09.003 |
| Popis: | The ability to predict patients with stage II colon cancer at high risk of recurrence is currently limited to certain clinicopathologic factors. This population-based study reviewed various prognostic factors to identify those associated with worse time to recurrence (TTR) and improved disease specific survival (DSS), and to subsequently develop a prognostic index (PI) to identify high risk cancers. Multivariate analyses revealed factors significant for TTR and DSS. A PI derived from the TTR risk factors identified 3 risk groups using 5-year rate without relapse: 88% for low-risk, 81% for intermediate-risk, and 59% for high-risk. This model was better at identifying high risk patients than using equally weighted standard risk factors. |
| Databáze: | OpenAIRE |
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