Current state of pediatric sarcoma biology and opportunities for future discovery: A report from the sarcoma translational research workshop
Autor: | D. Williams Parsons, Paul S. Meltzer, Sharon E. Plon, Douglas S. Hawkins, Crystal L. Mackall, Steven G. DuBois, Lisa Mirabello, R. Lor Randall, Katherine A. Janeway, Poul H. Sorensen, Ching C. Lau, Rajen Mody, Malcolm A. Smith, Carol J. Bult, Pooja Hingorani, Sharon A. Savage, Javed Khan, Richard Gorlick, Stephen X. Skapek, Cigall Kadoch, Damon R. Reed, Peter C. Adamson, Philip J. Lupo, Marc Ladanyi, Jack F. Shern, Brian D. Crompton, Stephen L. Lessnick, Joshua D. Schiffman, Chand Khanna |
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Rok vydání: | 2016 |
Předmět: |
Epigenomics
0301 basic medicine Cancer Research Biomedical Pediatric sarcoma Drug Evaluation Preclinical Translational Research Biomedical 0302 clinical medicine Clinical Protocols Recurrence Precision Medicine Cancer Pediatric Systemic chemotherapy Sarcoma Genomics Preclinical 030220 oncology & carcinogenesis Pediatric Research Initiative medicine.medical_specialty Pediatric Cancer molecular profiling precision medicine Oncology and Carcinogenesis patient derived xenografts Translational research Biology Article 03 medical and health sciences Rare Diseases Translational Research genomics Genetics medicine Animals Humans Oncology & Carcinogenesis Intensive care medicine Molecular Biology Germ-Line Mutation medicine.disease Precision medicine Xenograft Model Antitumor Assays sarcoma biology Clinical trial Orphan Drug 030104 developmental biology Immunology Drug Evaluation |
Zdroj: | Cancer genetics, vol 209, iss 5 |
ISSN: | 2210-7762 |
Popis: | Sarcomas are a rare subgroup of pediatric cancers comprised of a variety of bone and soft-tissue tumors. While significant advances have been made in improving outcomes of patients with localized pediatric sarcomas since the addition of systemic chemotherapy to local control many decades ago, outcomes for patients with metastatic and relapsed sarcoma remain poor with few novel therapeutics identified to date. With the advent of new technologies to study cancer genomes, transcriptomes and epigenomes, our understanding of sarcoma biology has improved tremendously in a relatively short period of time. However, much remains to be accomplished in this arena especially with regard to translating all of this new knowledge to the bedside. To this end, a meeting was convened in Philadelphia, PA on April 18, 2015 sponsored by the QuadW foundation, Children’s Oncology Group and CureSearch for Children’s Cancer that brought together sarcoma clinicians and scientists from North America to review the current state of pediatric sarcoma biology and ongoing/planned genomics based clinical trials in an effort to identify and bridge knowledge gaps that continue to exist at the current time. At the conclusion of the workshop, three key objectives that would significantly further our understanding of sarcoma were identified and a proposal was put forward to develop an all-encompassing pediatric sarcoma biology protocol that would address these specific needs. This review summarizes the proceedings of the workshop. |
Databáze: | OpenAIRE |
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