Current state of pediatric sarcoma biology and opportunities for future discovery: A report from the sarcoma translational research workshop

Autor: D. Williams Parsons, Paul S. Meltzer, Sharon E. Plon, Douglas S. Hawkins, Crystal L. Mackall, Steven G. DuBois, Lisa Mirabello, R. Lor Randall, Katherine A. Janeway, Poul H. Sorensen, Ching C. Lau, Rajen Mody, Malcolm A. Smith, Carol J. Bult, Pooja Hingorani, Sharon A. Savage, Javed Khan, Richard Gorlick, Stephen X. Skapek, Cigall Kadoch, Damon R. Reed, Peter C. Adamson, Philip J. Lupo, Marc Ladanyi, Jack F. Shern, Brian D. Crompton, Stephen L. Lessnick, Joshua D. Schiffman, Chand Khanna
Rok vydání: 2016
Předmět:
Epigenomics
0301 basic medicine
Cancer Research
Biomedical
Pediatric sarcoma
Drug Evaluation
Preclinical
Translational Research
Biomedical
0302 clinical medicine
Clinical Protocols
Recurrence
Precision Medicine
Cancer
Pediatric
Systemic chemotherapy
Sarcoma
Genomics
Preclinical
030220 oncology & carcinogenesis
Pediatric Research Initiative
medicine.medical_specialty
Pediatric Cancer
molecular profiling
precision medicine
Oncology and Carcinogenesis
patient derived xenografts
Translational research
Biology
Article
03 medical and health sciences
Rare Diseases
Translational Research
genomics
Genetics
medicine
Animals
Humans
Oncology & Carcinogenesis
Intensive care medicine
Molecular Biology
Germ-Line Mutation
medicine.disease
Precision medicine
Xenograft Model Antitumor Assays
sarcoma biology
Clinical trial
Orphan Drug
030104 developmental biology
Immunology
Drug Evaluation
Zdroj: Cancer genetics, vol 209, iss 5
ISSN: 2210-7762
Popis: Sarcomas are a rare subgroup of pediatric cancers comprised of a variety of bone and soft-tissue tumors. While significant advances have been made in improving outcomes of patients with localized pediatric sarcomas since the addition of systemic chemotherapy to local control many decades ago, outcomes for patients with metastatic and relapsed sarcoma remain poor with few novel therapeutics identified to date. With the advent of new technologies to study cancer genomes, transcriptomes and epigenomes, our understanding of sarcoma biology has improved tremendously in a relatively short period of time. However, much remains to be accomplished in this arena especially with regard to translating all of this new knowledge to the bedside. To this end, a meeting was convened in Philadelphia, PA on April 18, 2015 sponsored by the QuadW foundation, Children’s Oncology Group and CureSearch for Children’s Cancer that brought together sarcoma clinicians and scientists from North America to review the current state of pediatric sarcoma biology and ongoing/planned genomics based clinical trials in an effort to identify and bridge knowledge gaps that continue to exist at the current time. At the conclusion of the workshop, three key objectives that would significantly further our understanding of sarcoma were identified and a proposal was put forward to develop an all-encompassing pediatric sarcoma biology protocol that would address these specific needs. This review summarizes the proceedings of the workshop.
Databáze: OpenAIRE
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