Brain substrates activated by electroacupuncture of different frequencies (I): Comparative study on the expression of oncogene c-fos and genes coding for three opioid peptides
| Autor: | Yueping Hou, Ji-Sheng Han, Xiaomin Wang, Hui-Fu Guo, Yuan Fang, Jinhua Tian |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Narcotics
medicine.medical_specialty Neuropeptide Gene Expression Stimulation In situ hybridization c-Fos Cellular and Molecular Neuroscience Internal medicine Gene expression medicine Animals Rats Wistar Opioid peptide Molecular Biology In Situ Hybridization biology Brain Rats Endocrinology Electroacupuncture Opioid biology.protein Female Immediate early gene Proto-Oncogene Proteins c-fos medicine.drug |
| Zdroj: | Brain research. Molecular brain research. 43(1-2) |
| ISSN: | 0169-328X |
| Popis: | Low and high frequency electroacupuncture (EA)-produced analgesia have been shown to be mediated by different brain substrates and different opioid peptides. In this study, Fos-like immunoreactivity (FLI) and in situ hybridization of the three opioid mRNAs were used to examine the effect of low (2 Hz) and high (100 Hz) frequency EA on neuronal activities, and the expression of opioid genes. 2 Hz and 100 Hz EA induced a markedly different spatial patterns of Fos expression in the rat brain, suggesting there are distinct neuronal pathways underlying EA of different frequencies. Likewise, 2 Hz and 100 Hz EA exert differential effects on opioid gene expression: while 2 Hz EA induced a more extensive and intensive preproenkephalin (PPE) mRNA expression than 100 Hz EA, it had no effect on preprodynorphin (PPD) mRNA expression which was significantly increased by 100 Hz EA stimulation. In contrast, EA of both frequencies did not affect POMC mRNA expression. |
| Databáze: | OpenAIRE |
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