Effects of soy extract on pentylenetetrazol-induced seizures in ovariectomized rats
| Autor: | Mahmoud Hosseini, H Alavi, Mehdi Khodamoradi, Nemati Karimooy H, Toktam Mohammadpour, Reza Karami, Ebrahimzadeh Bideskan Ar |
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| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Ovariectomy Clonic seizure chemistry.chemical_compound Seizures Internal medicine High doses Medicine Animals Pentylenetetrazol Rats Wistar Saline business.industry Plant Extracts Single injection Rats Endocrinology Complementary and alternative medicine chemistry Ovariectomized rat Pentylenetetrazole Phytoestrogens Female Soybeans business Hormone medicine.drug |
| Zdroj: | Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine. 9(6) |
| ISSN: | 1672-1977 |
| Popis: | OBJECTIVE To investigate the effects of soy extract on pentylenetetrazol (PTZ)-induced seizures in ovariectomized (OVX) rats. METHODS Female Wistar rats were randomly divided into 4 groups (n=15 in each group) as follows: sham-operated, OVX, low-dose soy (LDS) and high-dose soy (HDS). The rats in each group were divided into two subgroups and received daily injection of a low dose of PTZ (40 mg/kg body weight, intraperitoneally, n=7 in each subgroup) for 14 d or a single injection of a high dose of PTZ (90 mg/kg body weight, intraperitoneally, n=8 in each subgroup). The rats of LDS and HDS groups were injected with 20 and 60 mg/kg body weight of soy extract intraperitoneally, respectively, just 30 min before each PTZ injection. The rats of the sham-operated and the OVX groups received saline instead of soy extract. After treatment, the rats were placed in a plexiglas cage and their behaviors were observed for 60 min. RESULTS The results of repeated injection of low dose of PTZ during 14 d showed that the seizure score of the rats of OVX group on days 3, 5, 8, 10, 11, 12, and 13 was lower than that of the sham-operated group (P |
| Databáze: | OpenAIRE |
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