An Approach to the Treatment of Vitiligo by Khellin
| Autor: | M N Aboul-Enein, B S El-Menshawi, A Abdel-Fattah, G M Wassel |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Adult
Male medicine.medical_specialty Khellin Adolescent Vitiligo Skin Pigmentation Dermatology Clinical study chemistry.chemical_compound Double-Blind Method medicine Humans Child Clinical Trials as Topic business.industry Middle Aged Control subjects medicine.disease Clinical trial Photochemotherapy Negative response chemistry Sunlight Female business |
| Zdroj: | Dermatology. 165:136-140 |
| ISSN: | 1421-9832 1018-8665 |
| DOI: | 10.1159/000249932 |
| Popis: | An anticipated effect of khellin, related to its chemical structure, in the photochemotherapy of amelanosis has been investigated. In a double-blind clinical study, khellin has been orally administered to 30 vitiligo patients for 4 months with subsequent exposure to natural sunlight. At the end of the trial period. 5 patients out of 30 (16.6%) repigmented 90–100%; 7 cases (23.3%) repigmented 50–60% of the vitiliginous areas treated; 11 (36.6%) repigmented 25% or less, and 7 subjects (23.3%) showed negative response. 30 control subjects failed to repigment at all. The achieved repigmentation was stable after drug cessation for a period of 1 year. These data add a previously unreported effect for the non-psoralen compound, khellin, in the therapy of vitiligo. |
| Databáze: | OpenAIRE |
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