Evaluation of oxidative stress and brain-derived neurotrophic factor levels related to crack-use detoxification
| Autor: | Henrique Morais Hamerski, Paulo Cesar Lock Silveira, Carlos Alberto Mayora Aita, Brenda da Silva, Gabriela Trevisan dos Santos, Gabriela Elisa Hirsch, Ferando Garcez Porto, Gustavo de Bem Silveira, Mônica Jaskulski, Jonatas Zeni Klafke, Karla Kroker, Paulo Ricardo Nazário Viecili |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty medicine.medical_treatment medicine.disease_cause Nitric Oxide Superoxide dismutase 03 medical and health sciences chemistry.chemical_compound Cocaine-Related Disorders Young Adult 0302 clinical medicine Neurotrophic factors Internal medicine Detoxification mental disorders medicine Humans Brain-derived neurotrophic factor biology business.industry Superoxide Dismutase General Neuroscience Brain-Derived Neurotrophic Factor Drug detoxification Glutathione Substance Withdrawal Syndrome Oxidative Stress 030104 developmental biology Endocrinology Glutathione S-transferase chemistry biology.protein Crack Cocaine business 030217 neurology & neurosurgery Oxidative stress Biomarkers |
| Zdroj: | Neuroscience letters. 670 |
| ISSN: | 1872-7972 |
| Popis: | Crack is a central nervous system stimulant extracted from the Erythroxylum coca plant. It is considered the most potent and addictive form of cocaine, and its euphoric effects are attained within a few seconds after consumption. Alteration of biological markers of oxidative stress and brain-derived neurotrophic factor (BDNF) could be related to the severity of crack withdrawal symptoms in patients undergoing rehabilitation. Thus, the objective of this study was to evaluate if the crack consumption and the drug detoxification process during 14 days in hospitalization regime was able to modify the oxidative status and BDNF levels, in male crack-abstinent patients. The crack detoxification process increased the glutathione (GSH), total thiol content (GST), nitric oxide (NO), and superoxide dismutase (SOD) levels, and reduced the mean BDNF levels. Moreover, a positive correlation was found between the number of hospital admission days and SOD values and between the GST levels and crack-use time after 14 days of detoxification. Furthermore, a negative correlation between the frequency of crack use and NO levels on the first day of hospitalization was also found. In conclusion, the results of this study indicated that crack consumption causes increased oxidative stress in drug users and that the detoxification process during 14 days was sufficient to improve oxidative parameters and antioxidant defenses of the patients, which could positively contribute to rehabilitation process. In addition, we also observed a great variability in the BDNF levels of the patients during the detoxification process, resulting in a reduction in the mean values of this neurotrophin. |
| Databáze: | OpenAIRE |
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